Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DISCRIMINATIVE STIMULUS PROPERTIES OF M-CHLOROPHENYLPIPERAZINE
Autore:
WINTER JC; RABIN RA;
Indirizzi:
SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT PHARMACOL & THERAPEUT,102 FARBER HALL BUFFALO NY 14214
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 45, anno: 1993,
pagine: 221 - 223
SICI:
0091-3057(1993)45:1<221:DSPOM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN; RAT; QUIPAZINE; 5-HT1B; BRAIN;
Keywords:
DRUG DISCRIMINATION; 5-HT1C; MCPP; TFMPP; MK-212; RU-24969;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Winter e R.A. Rabin, "DISCRIMINATIVE STIMULUS PROPERTIES OF M-CHLOROPHENYLPIPERAZINE", Pharmacology, biochemistry and behavior, 45(1), 1993, pp. 221-223

Abstract

Stimulus control was established in a group of 10 rats using a dose of m-chlorophenylpiperazine (MCPP) of 0.8 mg/kg, administered IP, 15 min before training. A two-lever operant task using a fixed-ratio 10 schedule of sweetened milk reinforcement was used. Based upon a criterionfor the presence of stimulus control of five consecutive sessions during which 83% or more of all responses were on the appropriate lever, a mean of 27 sessions was required to reach criterion performance. Response rates were significantly suppressed by the training dose of MCPP(14 responses/min) as compared with saline sessions (38 responses/min). Subsequent to the establishment of stimulus control, tests of generalization were conducted with m-trifluoromethylphenylpiperazine (TFMPP), 6-chloro-2-(1-piperazinyl)-pyrazine (MK-212), and 5-methoxy-3-(1,2 3,6-tetrahydro-4-pyridinyl)-1H-indole (RU-24969). MCPP generalized completely to MK-212 and TFMPP at doses of the latter drugs of 0.7 and 1.0 mg/kg, respectively. Maximum generalization to RU-24969 was 67% at adose of 1.0 mg/kg but only 4 of 10 subjects completed the test session. The present results indicate that MCPP is efficacious as a discriminative stimulus. In addition, because of MCPP's relative selectivity for the 5-hydroxytryptamine c(5-HT,c) receptor subjects trained with MCPP may prove valuable in assessing the respective functional contributions of 5-HT sites to the actions of a variety of serotonergic agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:59:41