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Titolo:
D(1) AND D(2) DOPAMINE RECEPTOR-MEDIATED MECHANISMS AND BEHAVIORAL SUPERSENSITIVITY
Autore:
MARIN C; PARASHOS SA; KAPITZOGLOULOGOTHETIS V; PEPPE A; CHASE TN;
Indirizzi:
NINCDS,EXPTL THERAPEUT BRANCH BETHESDA MD 20892 NINCDS,EXPTL THERAPEUT BRANCH BETHESDA MD 20892
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 45, anno: 1993,
pagine: 195 - 200
SICI:
0091-3057(1993)45:1<195:DADDRM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARDIVE DYSKINESIAS; D-1 RECEPTORS; BLOCKADE; SCH-23390; HALOPERIDOL; ANTAGONIST; CATALEPSY; APOMORPHINE; INCREASE; DRUGS;
Keywords:
DOPAMINE RECEPTOR INTERACTIONS; NEUROLEPTICS; TARDIVE DYSKINESIA; CATALEPSY; BEHAVIORAL SUPERSENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
C. Marin et al., "D(1) AND D(2) DOPAMINE RECEPTOR-MEDIATED MECHANISMS AND BEHAVIORAL SUPERSENSITIVITY", Pharmacology, biochemistry and behavior, 45(1), 1993, pp. 195-200

Abstract

The contribution of D1 and D2 dopamine (DA) receptor mechanisms to the behavioral supersensitivity and receptor upregulation induced by chronic DA antagonist administration were compared. Rats received either the selective D1 DA receptor antagonist SCH23390, the selective D2 DA receptor antagonist raclopride, their combination, or haloperidol, a predominantly D2 antagonist, for 21 days. Equivalent cataleptogenic doses of all drugs and drug combinations were employed. Tolerance to the cataleptic response was observed only in the haloperidol-treated group. Apomorphine-induced stereotypies were significantly enhanced in SCH23390-, raclopride-, and haloperidol-treated rats. In contrast, coadministration of both SCH23390 and raclopride had no effect on apomorphine-induced stereotypy. These findings suggest that neuroleptics blockingin equal proportion D1 and D2 receptor sites might be less likely to induce tardive dyskinesia and drug tolerance than those acting selectively on one or the other of these receptor subtypes.

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Documento generato il 18/09/20 alle ore 15:33:53