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Titolo:
SELECTIVE DETERMINATION OF ANTIMONY(III) AND ANTIMONY(V) IN SERUM ANDURINE AND OF TOTAL ANTIMONY IN SKIN BIOPSIES OF PATIENTS WITH CUTANEOUS LEISHMANIASIS TREATED WITH MEGLUMINE ANTIMONATE
Autore:
BURGUERA JL; BURGUERA M; DEPENA YP; LUGO A; ANEZ N;
Indirizzi:
UNIV LOS ANDES,FAC SCI,DEPT CHEM,POB 542 MERIDA VENEZUELA UNIV LOS ANDES,FAC SCI,DEPT BIOL MERIDA VENEZUELA
Titolo Testata:
Trace elements in medicine
fascicolo: 2, volume: 10, anno: 1993,
pagine: 66 - 70
SICI:
0174-7371(1993)10:2<66:SDOAAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM STIBOGLUCONATE; VISCERAL LEISHMANIASIS; RETENTION;
Keywords:
ANTIMONY; BLOOD SERUM; URINE; LEISHMANIASIS; GLUCANTIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Burguera et al., "SELECTIVE DETERMINATION OF ANTIMONY(III) AND ANTIMONY(V) IN SERUM ANDURINE AND OF TOTAL ANTIMONY IN SKIN BIOPSIES OF PATIENTS WITH CUTANEOUS LEISHMANIASIS TREATED WITH MEGLUMINE ANTIMONATE", Trace elements in medicine, 10(2), 1993, pp. 66-70

Abstract

We determined antimony(III) and antimony(V) in blood serum and urine and total antimony in skin biopsies of 5 patients with cutaneous leishmaniasis treated with meglumine antimonate (glucantime). The therapeutic dosages of the antimonial compound was of 60 mg per kg body weight daily for 10 d. Blood and urine samples were obtained at intervals before and after dosing and during treatment. The pharmacokinetics of both antimony(III) and antimony(V) species in blood and urine were remarkably similar. Blood serum antimony(III) (0.18 mg/1) and antimony(V) (1.12 mg/1) concentrations were higher five days after treatment, followed by a quick fall thereafter. Whereas, urine antimony(III) and antimony(V) after an initial maximun (274.14 and 206.60 mg/l, respectively) returned almost to normal 30 days after the end of treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 23:53:35