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Titolo:
RESECTION, BIOPSY, AND SURVIVAL IN MALIGNANT GLIAL NEOPLASMS - A RETROSPECTIVE STUDY OF CLINICAL-PARAMETERS, THERAPY, AND OUTCOME
Autore:
DEVAUX BC; OFALLON JR; KELLY PJ;
Indirizzi:
MAYO CLIN & MAYO FDN,DEPT NEUROSURG,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROSURG,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROL SURG ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,CANC CTR STAT UNIT ROCHESTER MN 55905 HOP ST ANNE,DEPT NEUROSURG F-75674 PARIS 14 FRANCE
Titolo Testata:
Journal of neurosurgery
fascicolo: 5, volume: 78, anno: 1993,
pagine: 767 - 775
SICI:
0022-3085(1993)78:5<767:RBASIM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFECTING POSTOPERATIVE SURVIVAL; RADIATION-THERAPY; GLIOBLASTOMA-MULTIFORME; RECURRENT GLIOBLASTOMA; ANAPLASTIC ASTROCYTOMA; PROGNOSTIC IMPORTANCE; STEREOTACTIC BIOPSY; SURGICAL RESECTION; LOW-GRADE; GLIOMAS;
Keywords:
BRAIN NEOPLASM; MALIGNANT GLIOMA; PROGNOSTIC FACTOR; STEREOTAXIS; QUALITY OF SURVIVAL; OUTCOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
B.C. Devaux et al., "RESECTION, BIOPSY, AND SURVIVAL IN MALIGNANT GLIAL NEOPLASMS - A RETROSPECTIVE STUDY OF CLINICAL-PARAMETERS, THERAPY, AND OUTCOME", Journal of neurosurgery, 78(5), 1993, pp. 767-775

Abstract

Between July, 1984, and October, 1988, 263 patients (163 male, 100 female), aged from 4 to 83 years (mean 52 years), with malignant brain gliomas underwent surgical procedures: stereotactic biopsy in 160 and resection in 103 patients. There were 170 grade IV astrocytomas, 17 grade IV mixed oligoastrocytomas, 44 grade III astrocytomas, 22 grade IIImixed oligoastrocytomas, and 10 malignant oligodendrogliomas. Overallmedian survival time was 30.1 weeks for grade IV gliomas, 87.7 weeks for grade III gliomas, and 171.3 weeks for malignant oligodendrogliomas. Multivariate analysis in 218 newly diagnosed cases revealed that the variables most strongly correlated with survival time were: tumor grade, patient age, seizures as a first symptom, a Karnofsky PerformanceScale score of less than 70%, tumor resection, and a radiation therapy dose greater than 50 Gy. The proportions of patients receiving tumorresection versus biopsy in each of these prognosis factor groups weresimilar. Since most of the 22 patients with midline and brain-stem tumors were treated with biopsy alone, these were excluded. Considering 196 newly diagnosed patients with cortical and subcortical tumors, grade IV glioma patients undergoing resection of the contrast-enhancing mass (as evidenced on computerized tomography and magnetic resonance imaging) and postoperative external beam radiation therapy lived longer than those undergoing biopsy only and radiation therapy (median survival time 50.6 weeks and 33.0 weeks, respectively; Smirnov test, p = 0.0380). However, survival in patients with resected grade III gliomas was no better than in those with biopsied grade III lesions (p = 0.746). The authors conclude that, in selected grade IV gliomas, resection ofthe contrast-enhancing mass followed by radiation therapy is associated with longer survival times than radiation therapy after biopsy alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:04:10