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Titolo:
INTRACRANIAL CHORDOMAS - A CLINICOPATHOLOGICAL AND PROGNOSTIC STUDY OF 51 CASES
Autore:
FORSYTH PA; CASCINO TL; SHAW EG; SCHEITHAUER BW; OFALLON JR; DOZIER JC; PIEPGRAS DG;
Indirizzi:
MAYO CLIN & MAYO FDN,DEPT NEUROL,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROL,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROL SURG,DIV RADIAT ONCOL,SURG PATHOL SECT ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,CANC CTR STAT UNIT ROCHESTER MN 55905
Titolo Testata:
Journal of neurosurgery
fascicolo: 5, volume: 78, anno: 1993,
pagine: 741 - 747
SICI:
0022-3085(1993)78:5<741:IC-ACA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; CRANIAL CHORDOMAS; CHONDROID CHORDOMA; SURVIVAL; TUMORS; ASTROCYTOMAS; SKULL; NASAL; BASE;
Keywords:
CHORDOMA; BRAIN NEOPLASM; RADIATION THERAPY; OUTCOME; PROGNOSTIC FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Forsyth et al., "INTRACRANIAL CHORDOMAS - A CLINICOPATHOLOGICAL AND PROGNOSTIC STUDY OF 51 CASES", Journal of neurosurgery, 78(5), 1993, pp. 741-747

Abstract

Fifty-one patients with intracranial chordomas who were surgically treated between 1960 and 1984 were studied. Median patient age was 46 years, and 73% presented with diplopia or headache. Nineteen tumors wereclassified as the ''chondroid'' type. The extent of surgical removal was a biopsy in 11 patients and subtotal removal or greater in 40. Thirty-nine patients received postoperative radiation therapy. At the time of analysis, 17 patients were alive, and the estimated 5- and 10-year survival rates were 51% and 35%, respectively, for the group of 51 patients. Univariate analysis showed that: 1) patients undergoing resection lived longer (the 5-year survival rate was 36% for the 11 biopsy patients compared with 55% for the 40 patients who had resection; 2) patients who underwent postoperative radiotherapy tended to have longerdisease-free survival times; and 3) overall and disease-free survivaldata were the same for patients with chondroid tumors and those with typical chordomas. Multivariate analysis showed that: 1) age was the factor most strongly associated with longer overall and disease-free survival: 2) diplopia was associated with longer survival; and 3) tumoral mitotic activity tended to be associated with shorter disease-free survival. One tumor metastasized to the cervical cord, and two tumors underwent anaplastic transformation. These data suggest that the prognosis in patients with chordomas is unfavorable, young age is the singlefactor most strongly associated with longer survival, surgical resection is beneficial, and postoperative radiotherapy may prolong disease-free survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 08:44:07