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Titolo:
CONCURRENT USE OF GANCICLOVIR AND FOSCARNET TO TREAT CYTOMEGALOVIRUS-INFECTION IN AIDS PATIENTS
Autore:
DIETERICH DT; POLES MA; LEW EA; MENDEZ PE; MURPHY R; ADDESSI A; HOLBROOK JT; NAUGHTON K; FRIEDBERG DN;
Indirizzi:
NYU MED CTR,DEPT GASTROENTEROL,SUITE 207,345 E 37TH ST NEW YORK NY 10016 UNIV MIAMI,SCH MED MIAMI FL 33152 JOHNS HOPKINS UNIV,CTR CLIN TRIALS BALTIMORE MD 21218 NORTHWESTERN UNIV,MED CTR CHICAGO IL 60611
Titolo Testata:
The Journal of infectious diseases
fascicolo: 5, volume: 167, anno: 1993,
pagine: 1184 - 1188
SICI:
0022-1899(1993)167:5<1184:CUOGAF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINITIS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
D.T. Dieterich et al., "CONCURRENT USE OF GANCICLOVIR AND FOSCARNET TO TREAT CYTOMEGALOVIRUS-INFECTION IN AIDS PATIENTS", The Journal of infectious diseases, 167(5), 1993, pp. 1184-1188

Abstract

Ten patients with AIDS and progressive cytomegalovirus disease were treated with ganciclovir and foscarnet concurrently. The patients had received ganciclovir and foscarnet monotherapy a median of 330 days before receiving combination therapy for a median of 80 days. Nine of the10 patients responded to the combination. No electrolyte abnormalities were noted during combination therapy, but rates of neutropenia (relative rate, combination vs. ganciclovir, 1.99; P = .229) and thrombocytopenia (relative rate, combination vs. ganciclovir, 1.53; P = .616) were higher with combination therapy than with either drug alone. The relative rate of anemia was significantly increased with combination therapy compared with monotherapy (relative rate, combination vs. ganciclovir, 2.69; P = .025). These data suggest that combination ganciclovir and foscarnet therapy after failure of either alone appears to be aseffective as standard therapy with single agents. The rate of anemia with combination therapy was significantly greater than either agent alone, but no significant difference was noted among the other parameters of toxicity studied.

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Documento generato il 12/07/20 alle ore 01:58:55