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Titolo:
ALTERED VASOCONSTRICTOR RESPONSIVENESS IN VITAMIN-D-INDUCED ARTERIOSCLEROTIC RAT AORTAS
Autore:
KITAGAWA S; YAMAGUCHI Y; KUNITOMO M; IMAIZUMI N; FUJIWARA M;
Indirizzi:
MUKOGAWA WOMENS UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,11-68 KOSHIEN KYUBAN CHO NISHINOMIYA HYOGO 663 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 4, volume: 61, anno: 1993,
pagine: 283 - 289
SICI:
0021-5198(1993)61:4<283:AVRIVA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; HERITABLE HYPERLIPIDEMIC RABBITS; VASCULAR REACTIVITY; HYPERCHOLESTEROLEMIC RABBITS; INDEPENDENT CONTRACTIONS; ISOLATED ARTERIES; CORONARY-ARTERY; RESPONSES; ATHEROSCLEROSIS; IMPAIRMENT;
Keywords:
ARTERIOSCLEROSIS; VITAMIN-D; HIGH-CHOLESTEROL DIET; CALCIFICATION; CONTRACTILE RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S. Kitagawa et al., "ALTERED VASOCONSTRICTOR RESPONSIVENESS IN VITAMIN-D-INDUCED ARTERIOSCLEROTIC RAT AORTAS", Japanese Journal of Pharmacology, 61(4), 1993, pp. 283-289

Abstract

This investigation was undertaken to characterize the vasoconstrictorresponsiveness in aortas isolated from a rat model of arteriosclerosis induced by vitamin D2 (VD) administration followed by feeding with ahigh-cholesterol diet. Cumulative contractile responses to KCl, noradrenaline and serotonin in thoracic aortic strips isolated from arteriosclerotic rats were slightly augmented in concentrations lower than the EC50 value of each agent and rather attenuated in their higher concentrations as compared with those from normal rats. Maximum contractions to the agonists were markedly attenuated in arteriosclerotic aortas;the degree of attenuation was greater in rats treated with a combination of VD and cholesterol than in those treated with VD alone. There was a significant negative correlation between the maximum contraction to KCl, noradrenaline or serotonin and the content of calcium or cholesterol ester in aortas. Removal of endothelium markedly enhanced sensitivity and contractility to the agonists in aortic strips from normal rats, whereas the same procedure only slightly enhanced them in aorticstrips from arteriosclerotic rats. These results indicate that in arteriosclerotic rat aortas, contractile responsiveness to agonists of vascular smooth muscle cells is impaired with deposition of calcium and cholesterol, and they suggest that augmentation of contractile responses to the agonists in lower concentrations is due to impairment of endothelial function.

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Documento generato il 28/11/20 alle ore 00:59:09