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Titolo:
REGULATION OF OXIDATIVE AND GLYCOGENOLYTIC ATP SYNTHESIS IN EXERCISING RAT SKELETAL-MUSCLE STUDIED BY P-31 MAGNETIC-RESONANCE SPECTROSCOPY
Autore:
KEMP GJ; SANDERSON AL; THOMPSON CH; RADDA GK;
Indirizzi:
ROYAL LIVERPOOL UNIV HOSP,DEPT ORTHOPAED & ACCID SURG,PRESCOT ST LIVERPOOL L69 3BX MERSEYSIDE ENGLAND JOHN RADCLIFFE HOSP,MRC,BIOCHEM & CLIN MAGNET RESONANCE UNIT OXFORD OX3 9DU ENGLAND
Titolo Testata:
NMR in biomedicine
fascicolo: 6, volume: 9, anno: 1996,
pagine: 261 - 270
SICI:
0952-3480(1996)9:6<261:ROOAGA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAST-TWITCH MUSCLE; WORK TRANSITIONS; PHOSPHOCREATINE RESYNTHESIS; ELECTRICAL-STIMULATION; OXYGEN-CONSUMPTION; AEROBIC METABOLISM; DYNAMIC EXERCISE; CALF MUSCLE; ENERGY-COST; RECOVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Kemp et al., "REGULATION OF OXIDATIVE AND GLYCOGENOLYTIC ATP SYNTHESIS IN EXERCISING RAT SKELETAL-MUSCLE STUDIED BY P-31 MAGNETIC-RESONANCE SPECTROSCOPY", NMR in biomedicine, 9(6), 1996, pp. 261-270

Abstract

P-31 magnetic resonance spectroscopy measurements of pH and the concentrations of orthophosphate and phosphocreatine were used to estimate rates of glycogenolytic and oxidative ATP synthesis in rat leg muscle during 6 min sciatic nerve stimulation at different rates (1-4 Hz). Tostudy the regulation of glycogenolysis during exercise, the apparent 'glycogenolytic capacity' (L(MAX)) was calculated from glycogenolytic ATP synthesis rate and orthophosphate concentration as a measure of the Ca2+-dependent activation of glycogen phosphorylase. This was found to be proportional to the total ATP synthesis rate (F), and to declinewith time; expressed relative to total ATP turnover rate as L(MAX)/F,its initial value was 2.9 +/- 0.6, declining with half-time 1.4 +/- 0.4 min. The apparent 'mitochondrial capacity' (Q(MAX)), calculated from oxidative ATP synthesis rate and [ADP], was independent of ATP turnover rate, but increased with half-time 0.8 +/- 0.1 min to 29 +/- 2 mmol kg(-1) min(-1): thus [ADP] was the predominant but not the only influence on oxidative ATP synthesis. Numerical simulation shows that time-dependent changes in L(MAX)/F exert a strong influence on pH and on the concentrations of phosphocreatine and ADP. (C) 1997 by John Wiley &Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:07:55