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Titolo:
DURATION AND POTENCY OF ANTICHOLECYSTOKININ ACTION OF SUBCUTANEOUS AND ORAL LOXIGLUMIDE ON CERULEIN-STIMULATED PANCREATIC EXOCRINE SECRETION
Autore:
WATANABE N; OTSUKI M;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT INTERNAL MED 3,YAHATANISHI KU KITAKYUSHU FUKUOKA 807 JAPAN
Titolo Testata:
International journal of pancreatology
fascicolo: 2, volume: 13, anno: 1993,
pagine: 129 - 137
SICI:
0169-4197(1993)13:2<129:DAPOAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ RECEPTOR ANTAGONIST; NEGATIVE FEEDBACK-CONTROL; CCK ANTAGONISTS; JUICE DIVERSION; RATS; GROWTH; L-364,718; PEPTIDE; RELEASE; PERSPECTIVES;
Keywords:
CCK ANTAGONIST; LOXIGLUMIDE; CERULEIN; PANCREATIC SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
N. Watanabe e M. Otsuki, "DURATION AND POTENCY OF ANTICHOLECYSTOKININ ACTION OF SUBCUTANEOUS AND ORAL LOXIGLUMIDE ON CERULEIN-STIMULATED PANCREATIC EXOCRINE SECRETION", International journal of pancreatology, 13(2), 1993, pp. 129-137

Abstract

The duration and the potency of the antiCCK activities of loxiglumidegiven by sc and oral routes were examined in rats. Pancreatic juice flow and protein output in response to an iv bolus injection of cerulein (100 ng/kg body wt) were measured at specified time intervals from 1-12 h after loxiglumide administration. Subcutaneous loxiglumide (10 g/kg body wt) effectively suppressed cerulein-stimulated protein outputfor 4 h and pancreatic juice volume for 6 h, when total outputs during a 60-min period after cerulein stimulation were compared with the control value without loxiglumide pretreatment. Oral dose of loxiglumideexerted longer-term anti-CCK activity (protein output: 6 h, pancreatic juice: 8 h) than the same sc dose. In addition, oral loxiglumide showed more potent suppression of protein output than the same sc dose atthe corresponding time interval. Higher oral dose of loxiglumide (50 mg/kg body wt) caused longer inhibition on both protein (8 h) and pancreatic juice secretion (12 h). These results suggest that the half-life of loxiglumide given by oral route is longer than that by sc route or that the bioavailability of oral loxiglumide is higher than that of sc dose. The present study demonstrates that loxiglumide, given eitherby sc or by oral route, has long duration of action in antagonizing responses to exogenously administered cerulein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:41:45