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Titolo:
ADDITIONAL PEPTIDYL DIAZOMETHYL KETONES, INCLUDING BIOTINYL DERIVATIVES, WHICH AFFINITY-LABEL CALPAIN AND RELATED CYSTEINYL PROTEINASES
Autore:
WIKSTROM P; ANAGLI J; ANGLIKER H; SHAW E;
Indirizzi:
FRIEDRICH MIESCHER INST,POSTFACT 2543 CH-4002 BASEL SWITZERLAND FRIEDRICH MIESCHER INST,POSTFACT 2543 CH-4002 BASEL SWITZERLAND PENTAPHARM AESCH SWITZERLAND
Titolo Testata:
Journal of enzyme inhibition
fascicolo: 4, volume: 6, anno: 1993,
pagine: 259 - 269
SICI:
8755-5093(1993)6:4<259:APDKIB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED NEUTRAL PROTEASE; CALCIUM-DEPENDENT PROTEASE; SITE-DIRECTED INHIBITORS; CATHEPSIN-B; SUBSTRATE DERIVATIVES; ENDOGENOUS INHIBITOR; THIOL PROTEINASES; IDENTIFICATION; FIBROBLASTS; PLATELETS;
Keywords:
CALPAIN; CYSTEINYL PROTEASES; INHIBITORS; PEPTIDYL DIAZOMETHYL KETONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
P. Wikstrom et al., "ADDITIONAL PEPTIDYL DIAZOMETHYL KETONES, INCLUDING BIOTINYL DERIVATIVES, WHICH AFFINITY-LABEL CALPAIN AND RELATED CYSTEINYL PROTEINASES", Journal of enzyme inhibition, 6(4), 1993, pp. 259-269

Abstract

Calpain, the calcium-activated cysteinyl proteinase, can be irreversibly inactivated by peptidyl diazomethyl ketones in which the peptide portion contains a penultimate leucine residue. Some new derivatives ofthis type have been synthesized and examined for their rates of inactivation of chicken gizzard and human platelet calpain. Two derivativescontaining a C-terminal biotin residue, Biot-Aca-Leu-TyrCHN2 and Biot-Aca-Leu-Leu-TyrCHN2, have also been prepared in the expectation that their application to the study of the function of calpain and related proteases will prove fruitful.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:19:58