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Titolo:
NITRIC-OXIDE INHIBITION INTENSIFIES COLD-RESTRAINT INDUCED GASTRIC-ULCERS IN RATS
Autore:
OGLE CW; QIU BS;
Indirizzi:
UNIV HONG KONG,FAC MED,DEPT PHARMACOL,5 SASSOON RD HONG KONG HONG KONG
Titolo Testata:
Experientia
fascicolo: 4, volume: 49, anno: 1993,
pagine: 304 - 307
SICI:
0014-4754(1993)49:4<304:NIICIG>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZINC-SULFATE; STRESS; DOPAMINE; STOMACH; SYSTEM;
Keywords:
N(W)-NITRO-1-ARGININE METHYL ESTER; NITRIC OXIDE; COLD-RESTRAINT STRESS; MUCOSAL ULCERS; MAST CELLS; RAT STOMACHS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Ogle e B.S. Qiu, "NITRIC-OXIDE INHIBITION INTENSIFIES COLD-RESTRAINT INDUCED GASTRIC-ULCERS IN RATS", Experientia, 49(4), 1993, pp. 304-307

Abstract

Treatment 20 min beforehand with an inhibitor of nitric oxide (NO) synthesis, N(w)-nitro-1-arginine methyl ester (L-NAME) (12.5, 25, 50 or 100 mg/kg, s.c.), dose-dependently intensified gastric glandular mucosal ulceration produced by cold-restraint stress. Hexamethonium (20 mg/kg) or atropine (1 mg/kg) pretreatment s.c. 20 min before stress strongly antagonised stress-evoked ulceration, as well as the ulcer-potentiating effects of L-NAME when either cholinoceptor antagonist was givenconcurrently with the NO inhibitor. Stress-induced mast cell degranulation was not worsened by L-NAME pretreatment. The findings suggest that NO could confer partial protection against stress-induced gastric ulcer formation; its activity is triggered off by the ulcerogenic mechanism of stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 02:10:16