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Titolo:
CHARACTERIZATION OF D117A AND H260A MUTATIONS IN THE MELANOCORTIN-1 RECEPTOR
Autore:
SCHIOTH HB; MUCENIECE R; SZARDENINGS M; PRUSIS P; LINDEBERG G; SHARMA SD; HRUBY VJ; WIKBERG JES;
Indirizzi:
UPPSALA UNIV,CTR BIOMED,DEPT PHARMACEUT PHARMACOL,BOX 591 S-75124 UPPSALA SWEDEN LATVIAN ACAD SCI,INST ORGAN SYNTH,PHARMACOL LAB LV-226006 RIGA LATVIA UPPSALA UNIV,DEPT MED & PHYSIOL CHEM UPPSALA SWEDEN UNIV ARIZONA,DEPT CHEM TUCSON AZ 85721
Titolo Testata:
Molecular and cellular endocrinology
fascicolo: 2, volume: 126, anno: 1997,
pagine: 213 - 219
SICI:
0303-7207(1997)126:2<213:CODAHM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-MELANOTROPIN; MOLECULAR-CLONING; BIOLOGICAL-ACTIVITY; EXPRESSION; HORMONE; ANALOGS; POTENT; MSH;
Keywords:
MC1 RECEPTOR; MSH; LIGAND BINDING; MUTAGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
H.B. Schioth et al., "CHARACTERIZATION OF D117A AND H260A MUTATIONS IN THE MELANOCORTIN-1 RECEPTOR", Molecular and cellular endocrinology, 126(2), 1997, pp. 213-219

Abstract

Recent site directed mutagenesis studies on the melanocortin 1 (MC1) receptor have indicated the importance of D117 and H260 amino acid residues for the binding of alpha-MSH (melanocyte stimulating hormone). Here, we report the testing of 12 cyclic and linear MSH peptides on theD117A and H260A mutant receptors. Moreover, we constructed a double mutant which displayed a major loss in affinity for [Nle(4), D-Phe(7)]alpha-MSH. Our new data of His(6) and Phe(7) substituted MSH peptides are compared with previous results and the hypothesis of putative interactions of D117 and H260 with single amino acids in the MSH peptide. Our conclusions are that the D117A and the H260A mutations may cause conformational changes in the receptor which can not be linked to any specific amino acid in the MSH-peptides. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:26:05