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Titolo:
RESPIRATORY MU-OPIOID AND BENZODIAZEPINE INTERACTIONS IN THE UNRESTRAINED RAT
Autore:
PAAKKARI P; PAAKKARI I; LANDES P; SIREN AL; FEUERSTEIN G;
Indirizzi:
UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,4301 JONES BRIDGE RD BETHESDA MD 20814 UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,4301 JONES BRIDGE RD BETHESDA MD 20814 UNIV HELSINKI,DEPT PHARMACOL & TOXICOL SF-00100 HELSINKI 10 FINLAND SMITHKLINE BEECHAM,DEPT PHARMACOL PHILADELPHIA PA 00000
Titolo Testata:
Neuropharmacology
fascicolo: 4, volume: 32, anno: 1993,
pagine: 323 - 329
SICI:
0028-3908(1993)32:4<323:RMABII>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST RO-15-1788; CENTRALLY-ADMINISTERED MORPHINE; NALOXONE BLOCKS; RO 15-1788; DERMORPHIN; BRAIN; GABA; DIAZEPAM; BINDING; STIMULATION;
Keywords:
DERMORPHIN; OPIOID-MU RECEPTORS; OPIOID BENZODIAZEPINE INTERACTIONS; RESPIRATION; FLUMAZENIL; BENZODIAZEPINE ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
P. Paakkari et al., "RESPIRATORY MU-OPIOID AND BENZODIAZEPINE INTERACTIONS IN THE UNRESTRAINED RAT", Neuropharmacology, 32(4), 1993, pp. 323-329

Abstract

Interactions of mu-opioid receptors with the benzodiazepine system were studied by examining the modulatory effects of flumazenil (a benzodiazepine antagonist) and alprazolam (a benzodiazepine agonist) on the respiratory effects of the opioid peptide dermorphin. Dermorphin, 1-30nmol administered i.c.v., to conscious, unrestrained rats decreased ventilation rate (VR) and minute volume (MV) dose-dependently. The ventilatory depression was antagonized by naloxone and by the benzodiazepine antagonist flumazenil. The benzodiazepine alprazolam potentiated the respiratory inhibition of a small (1 nmol) dose of dermorphin but antagonized that of a higher dos- (3 nmol). The results suggest that thebenzodiazepine/GABA receptor complex modulates respiratory depressioninduced by central mu-receptor stimulation in the rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:27:48