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Titolo:
APROTININ THERAPY IN CARDIAC OPERATIONS - A REPORT ON USE IN 41 CARDIAC CENTERS IN THE UNITED-KINGDOM
Autore:
BIDSTRUP BP; HARRISON J; ROYSTON D; TAYLOR KM; TREASURE T;
Indirizzi:
HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,CARDIOTHORAC SURG UNIT,DUCANERD LONDON W12 0NN ENGLAND WELLINGTON HOSP,CARDIOTHORAC UNIT WELLINGTON NEW ZEALAND HAREFIELD HOSP,CARDIOTHORAC UNIT HAREFIELD MIDDX ENGLAND BAYER UK NEWBURY BERKS ENGLAND ST GEORGE HOSP,CARDIOTHORAC UNIT LONDON ENGLAND HAMMERSMITH HOSP,CARDIOTHORAC UNIT LONDON W12 0HS ENGLAND
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 4, volume: 55, anno: 1993,
pagine: 971 - 976
SICI:
0003-4975(1993)55:4<971:ATICO->2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPEN-HEART SURGERY; HIGH-DOSE APROTININ; BLOOD-LOSS; CARDIOPULMONARY BYPASS; CORONARY-BYPASS; TRANSFUSION; PROSTACYCLIN; REDUCTION; NEED; ACID;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
B.P. Bidstrup et al., "APROTININ THERAPY IN CARDIAC OPERATIONS - A REPORT ON USE IN 41 CARDIAC CENTERS IN THE UNITED-KINGDOM", The Annals of thoracic surgery, 55(4), 1993, pp. 971-976

Abstract

Aprotinin, a serine protease inhibitor, has recently been shown to reduce blood loss in cardiac surgical patients. Data on the safety and efficacy of aprotinin therapy administered to 671 cardiac surgical patients in 41 United Kingdom cardiac surgical units have been submitted to interim analysis. The patients studied were in high-risk categories for excessive bleeding, including 457 redo operations and 79 patients with active infective endocarditis. Overall mortality was 12% in redo cases and 5.1% in first-time operations. Adverse events were reported in only 20 patients (3%). Median blood loss at 24 hours after operation was 400 mL, and median transfusion volume throughout the operative and postoperative period was 2 units. These data confirm that the use of aprotinin therapy in high-risk cardiac surgical patients is associated with a low incidence of adverse events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:51:39