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Titolo:
LONG-TERM TREATMENT WITH GLUCOCORTICOIDS INCREASES SYNTHESIS AND STABILITY OF JUNCTIONAL ACETYLCHOLINE-RECEPTORS ON INNERVATED CULTURED HUMAN MUSCLE
Autore:
BRAUN S; ASKANAS V; ENGEL WK; IBRAHIM EN;
Indirizzi:
UNIV SO CALIF,SCH MED,CTR NEUROMUSC,RON STEVER TISSUE CULTURE LAB,637S LUCAS AVE LOS ANGELES CA 90017 UNIV SO CALIF,SCH MED,CTR NEUROMUSC,RON STEVER TISSUE CULTURE LAB,637S LUCAS AVE LOS ANGELES CA 90017
Titolo Testata:
Journal of neurochemistry
fascicolo: 5, volume: 60, anno: 1993,
pagine: 1929 - 1935
SICI:
0022-3042(1993)60:5<1929:LTWGIS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; BETA-ADRENERGIC RECEPTORS; GROWTH-FACTOR RECEPTORS; MYASTHENIA-GRAVIS; NEUROMUSCULAR-JUNCTION; STEROID-HORMONES; CREATINE-KINASE; METABOLIC STABILIZATION; SKELETAL-MUSCLE; CYCLIC-AMP;
Keywords:
INNERVATED CULTURED HUMAN MUSCLE; ACETYLCHOLINE RECEPTORS; GLUCOCORTICOIDS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S. Braun et al., "LONG-TERM TREATMENT WITH GLUCOCORTICOIDS INCREASES SYNTHESIS AND STABILITY OF JUNCTIONAL ACETYLCHOLINE-RECEPTORS ON INNERVATED CULTURED HUMAN MUSCLE", Journal of neurochemistry, 60(5), 1993, pp. 1929-1935

Abstract

We have studied the effect of long-term treatment with hydrocortisoneon the expression of acetylcholine receptors (AChRs) at the neuromuscular junctions of human muscle cultured in monolayer and innervated denovo by fetal rat spinal cord motoneurons. Hydrocortisone increased accumulation of junctional AChRs in a dose- and time-dependent fashion. This increase was due to both decreased degradation and increased synthesis of AChRs. Other glucocorticoids, dexamethasone and prednisolone, exerted similar effects. Our study demonstrates a novel action of glucocorticoids on human junctional AChRs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:39:24