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Titolo:
PREVENTION OF RESPIRATORY-FAILURE AFTER HYDROCHLORIC-ACID ASPIRATION BY INTRATRACHEAL SURFACTANT INSTILLATION IN RATS
Autore:
EIJKING EP; GOMMERS D; SO KL; DEMAAT MPM; MOUTON JW; LACHMANN B;
Indirizzi:
ERASMUS UNIV,DEPT MED & PHYS THERAPY,ROOM EE 2393,POST BOX 1738 3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV,DEPT MED & PHYS THERAPY,ROOM EE 2393,POST BOX 1738 3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV,DEPT INTERNAL MED 2 3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV,DEPT CLIN MICROBIOL 3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Anesthesia and analgesia
fascicolo: 3, volume: 76, anno: 1993,
pagine: 472 - 472
SICI:
0003-2999(1993)76:3<472:PORAHA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISTRESS SYNDROME; EXOGENOUS SURFACTANT; GAS-EXCHANGE; LUNG LAVAGE; REPLACEMENT; MEMBRANE; PROTEIN; INJURY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Eijking et al., "PREVENTION OF RESPIRATORY-FAILURE AFTER HYDROCHLORIC-ACID ASPIRATION BY INTRATRACHEAL SURFACTANT INSTILLATION IN RATS", Anesthesia and analgesia, 76(3), 1993, pp. 472-472

Abstract

Because the surfactant system probably is involved in the pathophysiology of respiratory failure caused by hydrochloric acid (HCl) aspiration, we investigated the effects of different ventilation strategies and intratracheal surfactant instillation at different time intervals onthe course of pulmonary gas exchange after HCl aspiration in rats. Inthis study rats were anesthetized and mechanically ventilated via a tracheostomy. Respiratory failure was induced by intratracheal instillation of 3 mL/kg 0.1 N HCl. Animals (n = 49) were divided into nine groups: Groups 1 and 2 through 9 were ventilated with peak airway pressure/positive end-expiratory pressure of 14/2 and 26/6 cm H2O, respectively; Groups 3 and 4 received surfactant (200 mg/kg) intratracheally, 1 and 10 min after HCl aspiration; Groups 5 and 6 received saline, 1 and10 min after HCl aspiration; Groups 7 and 8 received surfactant, 60 and 90 min after HCl aspiration; Group 9 received saline instead of HCl. Gas exchange deteriorated in Groups 1, 2, 5, 6, 7, and 8, whereas respiratory failure could be prevented in Groups 3 and 4. After deterioration of gas exchange, surfactant treatment prevented further decreaseof PaO2 values in Group 7, whereas no effect on gas exchange was observed in Group 8; intratracheal instillation of saline had no effect ongas exchange (Group 9). These results suggest that surfactant should be given as early as possible after aspiration of gastric contents to prevent development of respiratory failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 03:34:57