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Titolo:
EFFECTS OF AGE, RACE, SEX, AND SMOKING ON PROTHROMBIN FRAGMENT 1.2 INA HEALTHY POPULATION
Autore:
HURSTING MJ; STEAD AG; CROUT FV; HORVATH BZ; MOORE BM;
Indirizzi:
ORGANON TEKNIKA CORP,100 AKZO AVE DURHAM NC 27704 ORGANON TEKNIKA CORP,100 AKZO AVE DURHAM NC 27704
Titolo Testata:
Clinical chemistry
fascicolo: 4, volume: 39, anno: 1993,
pagine: 683 - 686
SICI:
0009-9147(1993)39:4<683:EOARSA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION; HUMANS;
Keywords:
PROTHROMBIN; THROMBIN; COAGULATION ASSAYS; SEX-RELATED AND AGE-RELATED EFFECTS; SMOKING; REFERENCE INTERVAL; ENZYME-LINKED IMMUNOSORBENT ASSAY;
Tipo documento:
Note
Natura:
Periodico
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Hursting et al., "EFFECTS OF AGE, RACE, SEX, AND SMOKING ON PROTHROMBIN FRAGMENT 1.2 INA HEALTHY POPULATION", Clinical chemistry, 39(4), 1993, pp. 683-686

Abstract

Prothrombin fragment 1.2 (Fl.2) is a biomarker of thrombin generationduring blood coagulation and has diagnostic potential for assessing thrombotic risk and monitoring anticoagulation therapy. We used a monoclonal antibody-based immunoassay for plasma Fl.2 to establish a well-defined reference interval and to evaluate the effects of age, race, sex, and smoking status on F1.2 concentrations in a healthy population. Plasma samples and demographic information were obtained from 357 healthy individuals. F1.2 concentrations more closely followed a lognormalthan a gaussian frequency distribution. In a multiple linear-regression model in which the logarithms of F1.2 concentrations were regressedon age, race, sex, and smoking status, the significant explanatory variables were age and, to a lesser extent, sex and smoking. A segmented''hockey stick'' regression model indicated that F1.2 concentrations and age were unrelated for individuals <44 years old but were positively correlated above that age threshold. The estimated 95% tolerance interval (P = 0.95) for Fl.2 in healthy individuals <44 years old (n = 268) was 0.21-2.78 nmol/L. We conclude that age-matched Fl.2 reference intervals may be important for studies evaluating the diagnostic utility of F1.2 measurements, and that the clinical relevance of increased thrombin generation during aging warrants further investigation.

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Documento generato il 02/07/20 alle ore 22:18:42