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Titolo:
A NOVEL POSTTRANSLATIONAL MODIFICATION OF THE PEPTIDE ANTIBIOTIC SUBTILIN - ISOLATION AND CHARACTERIZATION OF A NATURAL VARIANT FROM BACILLUS-SUBTILIS ATCC-6633
Autore:
CHAN WC; BYCROFT BW; LEYLAND ML; LIAN LY; ROBERTS GCK;
Indirizzi:
UNIV NOTTINGHAM,DEPT PHARMACEUT SCI NOTTINGHAM NG7 2RD ENGLAND UNIV NOTTINGHAM,DEPT PHARMACEUT SCI NOTTINGHAM NG7 2RD ENGLAND UNIV LEICESTER,CTR BIOL NMR LEICESTER LE1 9HN ENGLAND UNIV LEICESTER,DEPT BIOCHEM LEICESTER LE1 9HN ENGLAND
Titolo Testata:
Biochemical journal
, volume: 291, anno: 1993,
parte:, 1
pagine: 23 - 27
SICI:
0264-6021(1993)291:<23:ANPMOT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NISIN;
Tipo documento:
Note
Natura:
Periodico
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
W.C. Chan et al., "A NOVEL POSTTRANSLATIONAL MODIFICATION OF THE PEPTIDE ANTIBIOTIC SUBTILIN - ISOLATION AND CHARACTERIZATION OF A NATURAL VARIANT FROM BACILLUS-SUBTILIS ATCC-6633", Biochemical journal, 291, 1993, pp. 23-27

Abstract

A variant of the peptide antibiotic subtilin has been isolated from Bacillus subtilis A.T.C.C. 6633, and its structure has been shown to be[N(alpha)-succinyl-Trp1]subtilin. The chemical structure of a fragment derived by tryptic hydrolysis of the variant is shown to be N(alpha)-succinyl-Trp-Lys by H-1 and C-13 n.m.r., fast-atom-bombardment m.s. and total chemical synthesis. [N(alpha)-Succinyl-Trp1]-subtilin is produced later in the growth of the bacterium than is subtilin; reverse-phase h.p.l.c. analysis shows that after 24 h growth the ratio subtilin/[N(alpha)-succinyl-Trp1]subtilin is approx. 1:2. Although [N(alpha)-succinyl-Trp1]subtilin retains significant antibacterial activity, it is10-20 times less active than subtilin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:18:51