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Titolo:
ASCENDING AFFERENT REGULATION OF RAT MIDBRAIN DOPAMINE NEURONS
Autore:
KELLAND MD; FREEMAN AS; RUBIN J; CHIODO LA;
Indirizzi:
WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT,CELLULAR & CLIN NEUROBIOL PROGRAM,2309 SCOTT HALL DETROIT MI 48201 SINAI RES INST,CTR CELL BIOL DETROIT MI 48235
Titolo Testata:
Brain research bulletin
fascicolo: 5, volume: 31, anno: 1993,
pagine: 539 - 546
SICI:
0361-9230(1993)31:5<539:AARORM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS TEGMENTI PEDUNCULOPONTINUS; CENTRAL NERVOUS-SYSTEM; PROGRESSIVE SUPRANUCLEAR PALSY; SUBSTANTIA NIGRA NEURONS; ELECTROPHYSIOLOGICAL EVIDENCE; INDUCED INHIBITION; 5-HT1A RECEPTORS; SENSORY STIMULI; DISCHARGE RATE; BASAL GANGLIA;
Keywords:
DORSAL RAPHE NUCLEUS; DPAT; KETAMINE; MESOACCUMBENS DA SYSTEM; NIGROSTRIATAL DA SYSTEM; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; SCIATIC NERVE; SKF 38393; TFMPP;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Kelland et al., "ASCENDING AFFERENT REGULATION OF RAT MIDBRAIN DOPAMINE NEURONS", Brain research bulletin, 31(5), 1993, pp. 539-546

Abstract

Standard, extracellular single-unit recording techniques were used toexamine the electrophysiological and pharmacological responsiveness of midbrain dopamine (DA) neurons to selected, ascending afferent inputs. Sciatic nerve stimulation-induced inhibition of nigrostriatal DA (NSDA) neurons was blocked by both PCPA (5-HT synthesis inhibitor) and 5,7-DHT (5-HT neurotoxin), suggesting mediation by a serotonergic (5-HT) system. Direct stimulation of the dorsal raphe (which utilizes 5-HT as a neurotransmitter and inhibits slowly firing NSDA neurons) inhibited all mesoaccumbens DA (MADA) neurons tested. Paradoxically, DPAT, a 5-HT1A agonist which inhibits 5-HT cell firing, enhanced sciatic nervestimulation-induced inhibition of NSDA neurons. MADA neurons were notinhibited by sciatic nerve stimulation and, therefore, could not be tested in this paradigm. In contrast to the dorsal raphe, electrical stimulation of the pedunculopontine tegmental nucleus preferentially excited slowly firing NSDA and MADA neurons. Thus, both excitatory and inhibitory ascending afferents influence the activity of midbrain DA neurons, and intact 5-HT systems are necessary for sciatic nerve stimulation to alter DA cell activity. However, the role that 5-HT plays in mediating peripheral sensory input remains unclear.

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Documento generato il 11/07/20 alle ore 15:56:13