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Titolo:
ACETYL-L-CARNITINE EFFECT ON PITUITARY AND PLASMA BETA-ENDORPHIN RESPONSIVENESS TO DIFFERENT CHRONIC INTERMITTENT STRESSORS
Autore:
BIDZINSKA B; PETRAGLIA F; ANGIONI S; GENAZZANI AD; CRISCUOLO M; FICARRA G; GALLINELLI A; TRENTINI GP; GENAZZANI AR;
Indirizzi:
UNIV MODENA,DEPT OBSTET & GYNECOL,VIA POZZO 71 I-41100 MODENA ITALY UNIV MODENA,DEPT OBSTET & GYNECOL,VIA POZZO 71 I-41100 MODENA ITALY UNIV MODENA,INST PATHOL ANAT I-41100 MODENA ITALY MED ACAD WROCLAW,DEPT ENDOCRINOL WROCLAW POLAND
Titolo Testata:
Journal of neuroendocrinology
fascicolo: 2, volume: 5, anno: 1993,
pagine: 151 - 155
SICI:
0953-8194(1993)5:2<151:AEOPAP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; RIBONUCLEIC-ACID LEVELS; MESSENGER-RNA; STIMULATES SECRETION; ANTERIOR-PITUITARY; OPIOID-PEPTIDES; RAT PITUITARY; INTERMEDIATE; LOBE; RESPONSES;
Keywords:
STRESS; SWIMMING STRESS; ETHER STRESS; ACETYL-L-CARNITINE; BETA-ENDORPHIN;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
B. Bidzinska et al., "ACETYL-L-CARNITINE EFFECT ON PITUITARY AND PLASMA BETA-ENDORPHIN RESPONSIVENESS TO DIFFERENT CHRONIC INTERMITTENT STRESSORS", Journal of neuroendocrinology, 5(2), 1993, pp. 151-155

Abstract

The aims of the present study were: 1) to compare the effect of two different chronic intermittent stressors i.e. cold-swimming versus ether, on the pituitary opioidergic system; 2) to evaluate the response ofpituitary and plasma beta-endorphin (beta-EP) to an acute stress in chronically stressed rats; and 3) to evaluate the effect of acetyl-l-carnitine treatment (10 mg/day/rat per os at night) on pituitary and plasma beta-EP changes induced by two different types of chronic stress. The stressors were applied twice a day for 10 days. Rats were killed either before, during or after the last swimming or ether stress session. Beta-EP was measured by radioimmunoassay in anterior pituitary and in neurointermediate lobe extracts and in plasma. The following observations were made: 1) Chronic intermittent cold-swimming stress increased anterior pituitary contents and plasma beta-EP levels; 2) both chronic intermittent cold-swimming stress and ether stress caused an increase of neurointermediate lobe beta-EP contents; 3) as in control animals, rats exposed to chronic intermittent swimming stress reduced pituitary beta-EP contents and raised plasma beta-EP levels in response to the last acute swimming stress; 4) in contrast to control animals, rats exposed to chronic intermittent ether stress did not show any significant response of the pituitary-plasma opioidergic system to the last acute ether session; 5) the acetyl-l-carnitine treatment counteracted the changes evoked by chronic intermittent cold-swimming stress on thepituitary and plasma beta-EP levels. The present data show that chronic intermittent ether stress impairs the capacity to respond to the acute stress and that acetyl-l-carnitine may modulate the changes of beta-EP levels following chronic cold-swimming stress exposure.

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Documento generato il 26/09/20 alle ore 23:15:08