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Titolo:
CLINICAL, ENDOCRINE AND NEUROCHEMICAL EFFECTS OF MOCLOBEMIDE IN DEPRESSED-PATIENTS
Autore:
ALEVIZOS B; HATZIMANOLIS J; MARKIANOS M; STEFANIS CN;
Indirizzi:
UNIV ATHENS,EGINITION HOSP,DEPT PSYCHIAT,74 VASSILISIS SOPHIAS AV GR-11528 ATHENS GREECE
Titolo Testata:
Acta psychiatrica Scandinavica
fascicolo: 4, volume: 87, anno: 1993,
pagine: 285 - 290
SICI:
0001-690X(1993)87:4<285:CEANEO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE SUPPRESSION TEST; URINARY MHPG-EXCRETION; MONOAMINE-OXIDASE; REVERSIBLE INHIBITOR; MAO INHIBITION; RO 11-1163; PLATELET; AMITRIPTYLINE; PHENELZINE; IMIPRAMINE;
Keywords:
MOCLOBEMIDE; MONOAMINE OXIDASE INHIBITOR, DEPRESSION; DEXAMETHASONE SUPPRESSION TEST; MHPG;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
B. Alevizos et al., "CLINICAL, ENDOCRINE AND NEUROCHEMICAL EFFECTS OF MOCLOBEMIDE IN DEPRESSED-PATIENTS", Acta psychiatrica Scandinavica, 87(4), 1993, pp. 285-290

Abstract

The clinical efficacy of the monoamine oxidase A inhibitor moclobemide and its effect on the dexamethasone suppression test (DST) and plasma and urine methoxyhydroxyphenylglycol (MHPG) were investigated in 26 depressed patients during a 4-week clinical trial. Fourteen patients (54%) responded favourably to the treatment (50% or more reduction of the Hamilton Rating Scale for Depression score). All (8) patients with an abnormal DST responded to treatment; 11 of 16 patients with a normal DST did not respond. Patients with low pretreatment MHPG excretion, according to the median value, were more frequently treatment responders. Plasma and urine MHPG were significantly decreased by treatment. The results indicate that low excretion of MHPG and cortisol nonsuppression may be considered as predictors of favourable clinical response to moclobemide treatment.

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Documento generato il 07/08/20 alle ore 00:45:09