Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE HUMAN PAPILLOMAVIRUS TYPE-16 E7 PROTEIN IS ASSOCIATED WITH THE NUCLEOLUS IN MAMMALIAN AND YEAST-CELLS
Autore:
ZATSEPINA O; BRASPENNING J; ROBBERSON D; HAJIBAGHERI MAN; BLIGHT KJ; ELY S; HIBMA M; SPITKOVSKY D; TRENDELENBURG M; CRAWFORD L; TOMMASINO M;
Indirizzi:
DEUTSCH KREBSFORSCHUNGSZENTRUM,ANGEW TUMORVIROL,INF 242 D-69120 HEIDELBERG GERMANY DEUTSCH KREBSFORSCHUNGSZENTRUM,ANGEW TUMORVIROL D-69120 HEIDELBERG GERMANY IMPERIAL CANC RES FUND LONDON WC2A 3PX ENGLAND DEUTSCH KREBSFORSCHUNGSZENTRUM,BIOMED STRUKTURFORSCH D-69120 HEIDELBERG GERMANY ST MARYS HOSP,SCH MED,WRIGHT FLEMING INST,DEPT MED MICROBIOL LONDON W2 1PG ENGLAND UNIV OTAGO,DEPT MICROBIOL,HRC VIRUS RES UNIT DUNEDIN NEW ZEALAND
Titolo Testata:
Oncogene
fascicolo: 10, volume: 14, anno: 1997,
pagine: 1137 - 1145
SICI:
0950-9232(1997)14:10<1137:THPTEP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOBLASTOMA GENE-PRODUCT; FISSION YEAST; SCHIZOSACCHAROMYCES-POMBE; TRANSCRIPTION FACTOR; NUCLEAR; E2F; LOCALIZATION; E7-PROTEIN; SEQUENCES; THIAMINE;
Keywords:
HPV; E7 PROTEIN; CELLULAR LOCALIZATION; NUCLEOLUS; MAMMALIAN AND YEAST CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
O. Zatsepina et al., "THE HUMAN PAPILLOMAVIRUS TYPE-16 E7 PROTEIN IS ASSOCIATED WITH THE NUCLEOLUS IN MAMMALIAN AND YEAST-CELLS", Oncogene, 14(10), 1997, pp. 1137-1145

Abstract

In this study we show, by immunofluorescence and electron microscopy immune-gold labelling, that the major transforming protein of Human Papillomavirus type 16 E7 is associated with the nucleolus of cells derived from the HPV16-positive cervical carcinoma line CaSki. The E7 nucleolar staining appeared to be cell cycle dependent, being considerablyreduced in the G(2) phase. The total level of the protein in the cell, however, remained constant during all phases, We also show that the cellular protein Rb1, which is targeted by E7, is localised in the nucleus and nucleolus in CaSki cells. Thus, it is possible that the presence of E7 in the nucleolus correlates with a hypothetical function(s) of Rb1 in this particular intranuclear compartment. The nucleolar localisation of HPV16 E7 protein was also observed in the fission yeast Schizosaccharomyces pombe, suggesting that a targeting mechanism of HPV16 E7 protein into the nucleolus is common to both mammalian and yeast systems, Nucleolar localisation of HPV16 E7 protein may be independentfrom Rb1 since no Rb1 related proteins have been identified in fission yeast.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:09:00