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Titolo:
EVALUATION OF POSTIMMUNIZATION PNEUMOCOCCAL TITERS IN CHILDREN WITH RECURRENT INFECTIONS AND NORMAL LEVELS OF IMMUNOGLOBULIN
Autore:
ZORA JA; SILK HJ; TINKELMAN DG;
Indirizzi:
ATLANTA ALLERGY CLIN,6667 VERNON WOODS DR,SUITE A-30 ATLANTA GA 30328
Titolo Testata:
Annals of allergy
fascicolo: 4, volume: 70, anno: 1993,
pagine: 283 - 288
SICI:
0003-4738(1993)70:4<283:EOPPTI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPSULAR POLYSACCHARIDE ANTIGEN; SUBNORMAL SERUM CONCENTRATIONS; INFLUENZAE TYPE-B; ANTIBODY-RESPONSE; IGG-SUBCLASS; DEFICIENCY; GLOBULIN; VACCINES; AGE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Zora et al., "EVALUATION OF POSTIMMUNIZATION PNEUMOCOCCAL TITERS IN CHILDREN WITH RECURRENT INFECTIONS AND NORMAL LEVELS OF IMMUNOGLOBULIN", Annals of allergy, 70(4), 1993, pp. 283-288

Abstract

Seven children were evaluated who had recurrent sinusitis, acute otitis media, pneumonia, and mastoiditis. All children had normal or near normal levels of IgG, IgA, and IgM. One child displayed a poor antibody response following tetanus and diphtheria immunization. Another child was noted to be atopic as determined by allergy skin tests. A polyvalent pneumococcal vaccine was administered to all children after 24 months of age, with the average age of administration being 33 months. Titers were obtained 3 to 6 weeks following immunization and were evaluated to 12 serotypes using radioimmunoassay. All seven patients failedto mount an adequate response to immunization and were treated with acourse of intravenous gammaglobulin. Five of seven children showed a distinct improvement in clinical course. Children with recurrent infections and normal levels of IgG may have a depressed ability lo respondto pneumococcal antigen. Evaluation of their response to pneumococcalvaccine can be used as a marker to determine their ability to make antibody specific responses to multiple infectious agents. The failure to make a specific antibody response may be one factor in the susceptibility of these patients to recurrent infections.

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Documento generato il 24/11/20 alle ore 08:19:54