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Titolo:
EFFECT OF L-364,718 (CCK RECEPTOR ANTAGONIST) ON EXOCRINE PANCREATIC-SECRETION OF ADRENALECTOMIZED RATS
Autore:
MANSO MA; DEDIOS I;
Indirizzi:
FAC BIOL SALAMANCA,DEPT FISIOL & FARMACOL E-37008 SALAMANCA SPAIN FAC BIOL SALAMANCA,DEPT FISIOL & FARMACOL E-37008 SALAMANCA SPAIN
Titolo Testata:
Pancreas
fascicolo: 3, volume: 8, anno: 1993,
pagine: 362 - 367
SICI:
0885-3177(1993)8:3<362:EOL(RA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACINAR AR42J CELLS; AMYLASE SECRETION; SUCKLING RATS; CERULEIN; STEROIDS; MODEL;
Keywords:
ADRENALECTOMY; CHOLECYSTOKININ RECEPTOR ANTAGONIST; EXOCRINE PANCREATIC SECRETION; L-364,718;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Manso e I. Dedios, "EFFECT OF L-364,718 (CCK RECEPTOR ANTAGONIST) ON EXOCRINE PANCREATIC-SECRETION OF ADRENALECTOMIZED RATS", Pancreas, 8(3), 1993, pp. 362-367

Abstract

The exocrine pancreatic secretion of control and adrenalectomized rats treated with L-364,718 was studied. The blockade of the action of endogenous cholecystokinin (CCK) in the control animals was reflected ina reduction of basal pancreatic secretion. This effect was reversed by the administration of submaximal doses of CCK-8. Under treatment with L-364,718, no decrease in pancreatic weight was observed. From this it may be deduced that factors other than CCK act on the pancreas to maintain the processes of enzyme synthesis and storage. Adrenalectomy reduced the weight of the pancreata; the main cause of this was the depletion of zymogen granules, which has been reported in adrenalectomized rats and is accompanied by a reduction in enzyme secretion, especially that of amylase. By contrast, the administration of L-364,718 from the very first moments after adrenalectomy leads to a retention of pancreatic enzymes. This effect is reflected in the maintenance of pancreatic weight and a secretory capacity in response to submaximal doses of CCK-8 similar to that of nonadrenalectomized animals. Accordingly, in the absence of glucocorticoids, endogenous CCK dominates the secretory process because when the action of this secretagogue is prevented by the administration of L-364,718, the discharge of proteins able to be secreted in response to a suitable stimulus is inhibited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:57:57