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Titolo:
MORPHOLOGICAL-CHANGES AND REORGANIZATION OF ACTINFILAMENTS IN HUMAN MYELOID-LEUKEMIA CELLS INDUCED BY A NOVEL PROTEIN PHOSPHATASE INHIBITOR, TAUTOMYCIN
Autore:
KURISAKI T; MAGAE J; NAGAI K; HIRATA A; KUSAKA I; SHINJI H; MORIKAWA M; YOSHIDA T; ISONO K; YAMASAKI M;
Indirizzi:
TOKYO INST TECHNOL,DEPT BIOENGN,4259 NAGATSUTA CHO,MIDORI KU YOKOHAMAKANAGAWA 227 JAPAN TOKYO INST TECHNOL,DEPT BIOENGN,4259 NAGATSUTA CHO,MIDORI KU YOKOHAMAKANAGAWA 227 JAPAN UNIV TOKYO,DEPT AGR CHEM,BUNKYO KU TOKYO 113 JAPAN TOKYO INST IMMUNOPHARMACOL INC,TOSHIMA KU TOKYO 171 JAPAN INST PHYS & CHEM RES WAKO SAITAMA 35101 JAPAN UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Cell structure and function
fascicolo: 1, volume: 18, anno: 1993,
pagine: 33 - 39
SICI:
0386-7196(1993)18:1<33:MAROAI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
OKADAIC ACID; TUMOR PROMOTER; CALYCULIN-A; SMOOTH-MUSCLE; SPONGE TOXIN; KINASE-C; ACTIVATION; VINCULIN; PHOSPHORYLATION; ACTIN;
Keywords:
TAUTOMYCIN; PROTEIN PHOSPHATASE; ACTINFILAMENT; CYTOSKELETON;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T. Kurisaki et al., "MORPHOLOGICAL-CHANGES AND REORGANIZATION OF ACTINFILAMENTS IN HUMAN MYELOID-LEUKEMIA CELLS INDUCED BY A NOVEL PROTEIN PHOSPHATASE INHIBITOR, TAUTOMYCIN", Cell structure and function, 18(1), 1993, pp. 33-39

Abstract

A protein phosphatase inhibitor, tautomycin induces blebs on the surface of human myeloid leukemia K562 cells within 10 min. In this paper we examined the cytoskeleton of tautomycin-treated cells. In the presence of tautomycin, cells with blebs turned into segmented forms with smooth surfaces after 15 min and into smooth round shapes without microprotuberance after 60 min. Observation with fluorescence microscopy showed that F-actin detached from the plasma membrane at the site of theblebs. Further treatment with tautomycin induced the accumulation of F-actin at the segmentation centers. Under electron microscopy, an electron dense ring-structure was detected at the segmentation center. Tautomycin did not induce major changes of the microtubule network although F-actin accumulated near the microtubule organizing center. The amount of F-actin increased in tautomycin-treated cells. These results indicate that the morphological changes are induced by reorganization of actinfilaments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:06:24