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Titolo:
PRENATAL DEVELOPMENT OF THE RECEPTIVE-FIELDS OF INDIVIDUAL TRIGEMINA GANGLION-CELLS IN THE RAT
Autore:
CHIAIA NL; BAUER WR; RHOADES RW;
Indirizzi:
MED COLL OHIO,DEPT ANAT TOLEDO OH 43699
Titolo Testata:
Journal of neurophysiology
fascicolo: 4, volume: 69, anno: 1993,
pagine: 1171 - 1180
SICI:
0022-3077(1993)69:4<1171:PDOTRO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONIC CHICK HINDLIMB; SPINAL-CORD; TOPOGRAPHIC ORGANIZATION; SOMATOSENSORY CORTEX; PRIMARY AFFERENTS; GRACILE NUCLEUS; DORSAL HORN; WGA-HRP; PROJECTIONS; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
N.L. Chiaia et al., "PRENATAL DEVELOPMENT OF THE RECEPTIVE-FIELDS OF INDIVIDUAL TRIGEMINA GANGLION-CELLS IN THE RAT", Journal of neurophysiology, 69(4), 1993, pp. 1171-1180

Abstract

1. Extracellular single-unit recording and receptive-field mapping techniques were used to evaluate the response characteristics of trigeminal (V) ganglion cells in unanesthetized, decerebrate, fetal rats between the ages of embryonic (E-) day 15 and E-20 (E-0 is the day of conception). 2. The receptive-field properties of the cells (n = 282) recorded at all of these ages except E-15 were remarkably similar; V primary afferents were generally silent in the absence of peripheral stimulation (94.3%) and gave rapidly adapting responses to innocuous tactilestimuli (97.5%). Rapid response decrements to repeated stimuli were observed in 9 of the 14 cells (64%) tested. 3. None of the cells recorded were activated by either heat or cold. No attempt was made to evaluate responses to noxious mechanical stimuli. 4. Particular attention was paid to neurons whose receptive fields involved mystacial vibrissaefollicles. At all ages, neurons were recorded that responded to indentation of the skin at the base of the vibrissae, but vibrissa deflection was not an adequate stimulus for any of the cells tested. At all ages, nearly all (89.0%) of the 127 cells with vibrissa-related receptive fields responded to indentation of one and only one follicle. 5. These results indicate that the response properties (e.g., adaptation characteristics, ability to respond to repeated stimuli) of V primary afferents in fetal rats differ substantially from those of V ganglion cells in adult animals, but that the receptive-field size for these neurons in prenatal rats is, with very rare exceptions, adult-like from theearliest age at which they can be recorded. 6. These results, when considered together with the results of previous retrograde tracing experiments in fetal animals, suggest that the initial projections of V primary afferents to their peripheral targets may be quite accurate.

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Documento generato il 12/07/20 alle ore 06:42:52