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Titolo:
SYMMETRY CONDITIONS FOR BINDING PROCESSES
Autore:
DICERA E; HOPFNER KP; WYMAN J;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT BIOCHEM & MOLEC BIOPHYS,BOX 8231 ST LOUIS MO 63110 UNIV COLORADO,DEPT CHEM & BIOCHEM BOULDER CO 80309
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 7, volume: 89, anno: 1992,
pagine: 2727 - 2731
SICI:
0027-8424(1992)89:7<2727:SCFBP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOGLOBIN;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
E. Dicera et al., "SYMMETRY CONDITIONS FOR BINDING PROCESSES", Proceedings of the National Academy of Sciences of the United Statesof America, 89(7), 1992, pp. 2727-2731

Abstract

Symmetry conditions are derived for global and local binding processes in biological macromolecules. It is shown that the conditions applying in the case of the macromolecule as a whole are decoupled from those referring to individual sites. In the case of two sites, the global binding curve is always symmetric, and the individual-site binding curves are always asymmetric, unless the two sites are identical or independent. In the case of three sites or more, individual-site binding curves can show symmetric or asymmetric behavior. The conditions derivedfor symmetry in the local description of binding processes also applyto the case of linkage among different ligands and to steady-state kinetics. Application to the analysis of oxygen binding to human hemoglobin under physiological conditions provides a model-independent interpretation of the asymmetric nature of the binding curve. Asymmetry of the global binding curve can coexist with symmetric or asymmetric binding to the individual alpha and beta chains. If the binding curves of the two chains are symmetric, then subunit heterogeneity and asymmetricinteractions must exist in the hemoglobin tetramer. On the other hand, if the binding curves of the two chains are asymmetric, then subunitheterogeneity and asymmetric interactions are not necessary for global asymmetric binding.

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Documento generato il 01/10/20 alle ore 07:45:27