Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TISSUE-SPECIFIC REGULATION OF VASOACTIVE-INTESTINAL-PEPTIDE MESSENGER-RIBONUCLEIC-ACID LEVELS BY ESTROGEN IN THE RAT
Autore:
KASPER S; POPESCU RA; TORSELLO A; VRONTAKIS ME; IKEJIANI C; FRIESEN HG;
Indirizzi:
UNIV MANITOBA,FAC MED,DEPT PHYSIOL,770 BANNATYNE AVE WINNIPEG R3E 0W3MANITOBA CANADA DIPARTIMENTO FARMACOL R4 I-20129 MILAN ITALY
Titolo Testata:
Endocrinology
fascicolo: 4, volume: 130, anno: 1992,
pagine: 1796 - 1801
SICI:
0013-7227(1992)130:4<1796:TROVM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOPHYSEAL PORTAL BLOOD; ANTERIOR-PITUITARY; PROLACTIN SECRETION; POLYPEPTIDE; VIP; RELEASE; GENE; STIMULATION; EXPRESSION; ESTRADIOL;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
S. Kasper et al., "TISSUE-SPECIFIC REGULATION OF VASOACTIVE-INTESTINAL-PEPTIDE MESSENGER-RIBONUCLEIC-ACID LEVELS BY ESTROGEN IN THE RAT", Endocrinology, 130(4), 1992, pp. 1796-1801

Abstract

The early and chronic effects of 17-beta-estradiol on vasoactive intestinal peptide (VIP) gene expression in rats were examined. Total RNA of four VIP-producing tissues were subjected to Northern blot analysis15 and 30 min, and 1, 3, 6, and 24 h after a single injection of 17-beta-estradiol (100-mu-g/kg ip). Pituitary, hypothalamus, brain, and ileum VIP messenger RNA (mRNA) levels rose in a time-dependent manner after estrogen treatment. In the pituitary, the increase was maximal at 30-60 min, whereas in the hypothalamus, the increase reached significance only at 3 h but then persisted until at least 24 h. In the brain, a transient increase in VIP mRNA was observed at 30 min, whereas VIP mRNA levels in the ileum responded in a biphasic pattern; the initial early increase was followed by a second elevation occurring at 6 h. A smaller 1-kilobase VIP-related transcript particularly abundant in the pituitary was regulated in parallel with the 1.7-kilobase mature VIP mRNA species. Continuous estrogen stimulation for 7 weeks dramatically increased both mRNA species in the pituitary but did not affect VIP mRNA levels in the other tissues. These data suggest that the regulationof VIP gene expression by transient increases in estrogen levels is rapid and that the pattern of induction is tissue specific.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:08:28