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Titolo:
LH PULSATILITY AND INVITRO BIOACTIVITY IN WOMEN WITH ANOREXIA NERVOSA-RELATED HYPOTHALAMIC AMENORRHEA
Autore:
ALLOUCHE J; BENNET A; BARBE P; PLANTAVID M; CARON P; LOUVET JP;
Indirizzi:
CHU PURPAN,SERV ENDOCRINOL F-31059 TOULOUSE FRANCE HOP LA GRAVE,BIOCHIM LAB 3 F-31052 TOULOUSE FRANCE
Titolo Testata:
Acta endocrinologica
fascicolo: 6, volume: 125, anno: 1991,
pagine: 614 - 620
SICI:
0001-5598(1991)125:6<614:LPAIBI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE SECRETION; GONADOTROPIN-SECRETION; REDUCED FREQUENCY; WEIGHT-LOSS; PATTERN;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
J. Allouche et al., "LH PULSATILITY AND INVITRO BIOACTIVITY IN WOMEN WITH ANOREXIA NERVOSA-RELATED HYPOTHALAMIC AMENORRHEA", Acta endocrinologica, 125(6), 1991, pp. 614-620

Abstract

LH nocturnal pulsatility and bioactivity to immunoreactivity (B/I) ratio were determined in 16 patients with anorexia nervosa-related hypothalamic amenorrhea and low sex steroid levels, and in 12 normal women in the midfollicular phase. The patients were subdivided into 2 groups: IA (N = 7) without, and IB (N = 9) with documented recent weight gain. Blood samples were taken from each subject at 10-min intervals from00.00 to 06.00 h. Immunoreactive LH data were analysed with cluster analysis algorithm. A pool of aliquots from all the samples was used toevaluate bioactive LH, immunoreactive LH and LH B/I ratio in each subject. LH pulse frequency was lower in Group IA than in controls, whereas it did not differ significantly between Group IB and controls. LH pulse amplitude was lower in Group IA, and higher in Group IB than in controls. LH B/I ratio was below the control range in 3/16 patients. Inconclusion, persistent hypothalamic amenorrhea does not require a permanent inhibition of the GnRH pulse generator; transient inhibition ofpulsatility and qualitative abnormalities of gonadotropins could be involved in the mechanism, at least in some patients.

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Documento generato il 03/12/20 alle ore 16:08:01