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Titolo:
THERAPY WITH CLOZAPINE
Autore:
STEVENS I; GAERTNER HJ;
Indirizzi:
UNIV TUBINGEN,PSYCHIAT KLIN,ALLGEMEINE PSYCHIAT POLIKLIN ABT,OSIANDERSTR 22 W-7400 TUBINGEN 1 GERMANY
Titolo Testata:
Nervenheilkunde
fascicolo: 2, volume: 11, anno: 1992,
pagine: 91 - 98
SICI:
0722-1541(1992)11:2<91:TWC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
GER
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; INDUCED AGRANULOCYTOSIS; TARDIVE-DYSKINESIA; NEUROTRANSMITTER RECEPTORS; DOPAMINERGIC-NEURONS; NEUROLEPTIC DRUGS; LIMBIC SYSTEM; SCHIZOPHRENIA; PSYCHOSIS; HALOPERIDOL;
Keywords:
CLOZAPINE; PHARMACOLOGY; CLINICAL USE; SIDE EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
I. Stevens e H.J. Gaertner, "THERAPY WITH CLOZAPINE", Nervenheilkunde, 11(2), 1992, pp. 91-98

Abstract

Clozapine is called an atypical neuroleptic drug. In animal models the effects differ from those of classical neuroleptics, e.g. catalepsy is not induced. Clozapine equally blocks dopaminergic receptors of D1-and D2-type and has strong effects on 5-HT2, H-1, alpha(1)- and alpha(2)-adrenergic as well as muscarinergic receptors. Clinical implications of interactions with D3-, D4-, 5-HT3-, GABA- and glutamate receptors are open to discussion. Antipsychotic effects are good in schizophrenia, but also reported e.g. in L-DOPA-induced psychosis in Parkinson'sdisease. The development of tardive dyskinesia was not described, even under longterm treatment; some reports even postulate a positive influence on various dyskinetic syndromes. In patients with post-psychotic depression or prevailing negative symptoms clozapine is superior to other neuroleptic drugs. The same was confirmed with regard to therapy-resistant schizophrenic patients or those who developed severe motor side effects under classical neuroleptics. The most frequent side effects are sedation, hypotension, anticholinergic effects and epileptic fits. The occurrence of possibly fatal agranulocytosis is supposed to be more frequent than under phenothiazines.

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Documento generato il 27/01/20 alle ore 16:48:48