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Titolo:
ACTIVATION OF CCK-A RECEPTORS INDUCES ELEVATION OF PLASMA-CORTICOSTERONE IN RATS
Autore:
KATSUURA G; IBII N; MATSUSHITA A;
Indirizzi:
SHIONOGI & CO LTD,SHIONOGI RES LAB,12-4 SAGISU 5-CHOME,FUKUSHIMA KU OSAKA 553 JAPAN
Titolo Testata:
Peptides
fascicolo: 1, volume: 13, anno: 1992,
pagine: 203 - 205
SICI:
0196-9781(1992)13:1<203:AOCRIE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ OCTAPEPTIDE; ADRENOCORTICAL SECRETION; ANTAGONIST RADIOLIGAND; BRAIN; STIMULATION; BINDING; POTENT;
Keywords:
CCK-8; CERULETIDE; CCK-A RECEPTORS; CCK-B RECEPTORS; (-)L-364,718; (+)L-365,260; PLASMA CORTICOSTERONE;
Tipo documento:
Note
Natura:
Periodico
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
G. Katsuura et al., "ACTIVATION OF CCK-A RECEPTORS INDUCES ELEVATION OF PLASMA-CORTICOSTERONE IN RATS", Peptides, 13(1), 1992, pp. 203-205

Abstract

Cholecystokinin octapeptide (CCK-8) and ceruletide (1-mu-g/kg) produced a pronounced increment of plasma corticosterone levels at 30 min after intraperitoneal administration. The response to these peptides wassuppressed by pretreatment with a selective antagonist for CCK-A receptors, (-)L-364,718, in a dose-related manner, but not with an antagonist for CCK-B receptors. (+)L-365,260. However. (-)L-364,718 itself had no effect on basal levels of plasma corticosterone. These results indicate that peripheral administration of CCK-8 and ceruletide stimulates the hypothalamo-pituitary adrenal axis through the activation of CCK-A receptors, but not CCK-B receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:58:20