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Titolo:
EFFECTS OF CCK ANTAGONISTS ON CCK-INDUCED SUPPRESSION OF LOCOMOTOR-ACTIVITY IN MICE
Autore:
HIROSUE Y; INUI A; MIURA M; NAKAJIMA M; OKITA M; HIMORI N; BABA S; KASUGA M;
Indirizzi:
KOBE UNIV,SCH MED,DEPT INTERNAL MED 2,KUSUNOKI CHO,CHUO KU KOBE 650 JAPAN NIPPON ROCHE RES CTR,DEPT PHARMACOL KAMAKURA 247 JAPAN HYOGO INST RES ADULT DIS AKASHI 673 JAPAN
Titolo Testata:
Peptides
fascicolo: 1, volume: 13, anno: 1992,
pagine: 155 - 157
SICI:
0196-9781(1992)13:1<155:EOCAOC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ ANTAGONIST; L-364,718; RECEPTOR; POTENT; BRAIN; L-365,260; RAT;
Keywords:
L-364,718; L-365,260; CHOLECYSTOKININ; LOCOMOTOR ACTIVITY; MICE; CCK-A RECEPTORS; CCK-B RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
Y. Hirosue et al., "EFFECTS OF CCK ANTAGONISTS ON CCK-INDUCED SUPPRESSION OF LOCOMOTOR-ACTIVITY IN MICE", Peptides, 13(1), 1992, pp. 155-157

Abstract

Sulfated cholecystokinin octapeptide (CCK-8) was administered either intraperitoneally or into the cerebral ventricle of fully conscious mice, and locomotor activity was quantified. CCK-8 administered by either route suppressed locomotor activity. Subcutaneously administered selective CCK-A receptor antagonist, L-364.718 (1 mg/kg), reversed the inhibitory effect of centrally as well as peripherally administered CCK-8, but the selective CCK-B receptor antagonist, L-365,260 (1 mg/kg), did not. These results demonstrate that centrally as well as peripherally administered CCK-8 suppresses locomotor activity in mice through aninteraction with CCK-A, but not CCK-B, receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:11:15