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Titolo:
PULSED LASER AND THERMAL ABLATION OF ATHEROSCLEROTIC PLAQUE - MORPHOMETRICALLY DEFINED SURFACE THROMBOGENICITY IN STUDIES USING AN ANNULAR PERFUSION CHAMBER
Autore:
LAWRENCE JB; PREVOSTI LG; KRAMER WS; SMITH PD; BONNER RF; LU DY; LEON MB;
Indirizzi:
CASE WESTERN RESERVE UNIV,INST PATHOL,2085 ADELBERT RD CLEVELAND OH 44106 NHLBI,DEPT CLIN PATHOL,SERV HEMATOL BETHESDA MD 20892 NHLBI,CARDIOL BRANCH,CLIN CTR BETHESDA MD 20892 NIH,DIV RES SERV,BIOMED ENGN & INSTRUMENTAT BRANCH BETHESDA MD 20892
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 5, volume: 19, anno: 1992,
pagine: 1091 - 1100
SICI:
0735-1097(1992)19:5<1091:PLATAO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUMINAL CORONARY ANGIOPLASTY; GLYCOPROTEIN-IIB-IIIA; PERIPHERAL ARTERY OCCLUSIONS; ASSISTED BALLOON ANGIOPLASTY; ADHESIVE PROTEIN-BINDING; BLOOD-CELL DEFORMABILITY; PLATELET-ADHESION; SHEAR RATE; VONWILLEBRAND-FACTOR; THROMBUS FORMATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Lawrence et al., "PULSED LASER AND THERMAL ABLATION OF ATHEROSCLEROTIC PLAQUE - MORPHOMETRICALLY DEFINED SURFACE THROMBOGENICITY IN STUDIES USING AN ANNULAR PERFUSION CHAMBER", Journal of the American College of Cardiology, 19(5), 1992, pp. 1091-1100

Abstract

Although clinical trials using laser and thermal angioplasty devices have been underway, the effects of pulsed laser and thermal ablation of atherosclerotic plaque on surface thrombogenicity are poorly understood. This study examined the changes in platelet adherence and thrombus formation on freshly harvested atherosclerotic aorta segments from Watanabe-heritable hyperlipidemic rabbits after ablation by two pulsed laser sources (308-nm xenon chloride excimer and 2,940-nm erbium:yttrium-aluminum-garnet [YAG] lasers) and a prototype catalytic hot-tip catheter. Specimens were placed in a modified Baumgartner annular chamberand perfused with citrated whole human blood, followed by quantitative morphometric analysis to determine the percent surface coverage by adherent platelets and thrombi in the treated and contiguous control areas. Pulsed excimer laser ablation of plaque did not change platelet adherence or thrombus formation in the treated versus control zones. However, photothermal plaque ablation with a pulsed erbium:YAG laser resulted in a 67% reduction in platelet adherence, compared with levels in control areas (from 16.7 +/- 2.2% to 5.5 +/- 1.8%; p < 0.005). Similarly, after plaque ablation using a catalytic thermal angioplasty device, there was a 74% reduction in platelet adherence (from 29.2 +/- 5.1% to 7.7 +/- 1.6%; p < 0.005) and a virtual absence of platelet thrombi (from 8.6 +/- 2.3% to 0.03 +/- 0.03%; p < 0.005). This reduced surface thrombogenicity after plaque ablation with either an erbium: YAG laser or a catalytic hot-tip catheter suggests that thermal modifications in the arterial surface ultra-structure or thermal denaturation of surface proteins, or both, may be responsible for reduced platelet adherence. These in vitro findings indicate that controlled thermal plaqueablation by catheter-based techniques may elicit endovascular responses that can reduce early thrombus formation during angioplasty procedures.

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Documento generato il 14/07/20 alle ore 19:51:02