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Titolo:
COMPARATIVE EFFECTS OF FENOLDOPAM MESYLATE AND NITROPRUSSIDE ON LEFT-VENTRICULAR PERFORMANCE IN SEVERE SYSTEMIC HYPERTENSION
Autore:
HACKMAN BB; GRIFFIN B; MILLS M; RAMANATHAN KB;
Indirizzi:
UNIV TENNESSEE CTR HLTH SCI,DEPT MED,DIV CARDIOL MEMPHIS TN 38163
Titolo Testata:
The American journal of cardiology
fascicolo: 9, volume: 69, anno: 1992,
pagine: 918 - 922
SICI:
0002-9149(1992)69:9<918:CEOFMA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR AGONIST; BLOOD-PRESSURE REDUCTION; INTRAVENOUS FENOLDOPAM; SODIUM-NITROPRUSSIDE; HEART-FAILURE; F 82526; THERAPY; STIMULATION; CARVEDILOL; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
B.B. Hackman et al., "COMPARATIVE EFFECTS OF FENOLDOPAM MESYLATE AND NITROPRUSSIDE ON LEFT-VENTRICULAR PERFORMANCE IN SEVERE SYSTEMIC HYPERTENSION", The American journal of cardiology, 69(9), 1992, pp. 918-922

Abstract

To compare the effects of fenoldopam (n = 15), a selective dopamine-1agonist, and nitroprusside (n = 14) on left ventricular (LV) functionin severely hypertensive subjects (diastolic blood pressure (BP) > 120 mm Hg), both agents were infused to reduce diastolic BP by 40 mm Hg (or < 110 mm Hg). Indexes of LV systolic and diastolic functions were obtained using gated radionuclide angiography before the initiation oftreatment and after targeted BP was achieved. Both fenoldopam and nitroprusside effectively reduced systolic and diastolic BP to target levels. Changes in heart rate, peak filling rate and relative end-diastolic volume were similar with both agents. Baseline ejection fraction increased after infusion of both drugs. The magnitude of the increase inejection fraction was far greater with fenoldopam than with nitroprusside (+22% vs +8%; p = 0.04), despite a lesser reduction in systolic BP (-12 vs -22%, p = 0.002). Furthermore, the reduction in relative end-systolic volume (-35 vs -20%; p = 0.04), and increase in the ratio ofpeak systolic pressure to relative end-systolic volume (+43 vs +6%; p= 0.007) were greater after fenoldopam than after nitroprusside. The greater increment in parameters of LV systolic function produced by fenoldopam than by nitroprusside suggests an effect on LV performance that is independent of afterload reduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:37:22