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Titolo:
SYNTHESIS, CHARACTERIZATION AND BIODISTRIBUTION OF A NEW HEXADENTATE AMINETHIOL LIGAND LABELED WITH TC-99M
Autore:
JOHN CS; SCHLEMPER EO; HOSAIN P; PAIK CH; REBA RC;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,RADIOPHARMACEUT CHEM SECT,662 ROSS HALL,2300 I ST NW WASHINGTON DC 20037 UNIV MISSOURI,DEPT CHEM COLUMBIA MO 65211
Titolo Testata:
International journal of radiation applicatons and instrumentation. Part B: Nuclear medicine and biology
fascicolo: 3, volume: 19, anno: 1992,
pagine: 269 - 274
SICI:
0969-8051(1992)19:3<269:SCABOA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
C.S. John et al., "SYNTHESIS, CHARACTERIZATION AND BIODISTRIBUTION OF A NEW HEXADENTATE AMINETHIOL LIGAND LABELED WITH TC-99M", International journal of radiation applicatons and instrumentation. Part B: Nuclear medicine and biology, 19(3), 1992, pp. 269-274

Abstract

A new hexadentate aminethiol ligand (TACNS) derived from triazacyclononane was synthesized and characterized for the development of technetium radiopharmaceuticals. The ligand formed a neutral, lipophilic and stable complex with [Tc-99m]pertechnetate in the presence of tin(II)tartrate as a reducing agent. The biodistribution of [Tc-99m]TACNS indicates slight uptake in brain (0.23% ID/organ at 5 min) with a washout at 30 min to 0.14% ID/organ. A small uptake in heart (0.48% ID at 5 min) was also observed. The characterization of [Tc-99m]TACNS complex using single crystal x-ray analysis and mass spectroscopy has shown that an Sn-N3S3 complex was formed in which tin is oxidized from Sn(II) to Sn(IV). Pertechnetate was incorporated into the complex as counter anion. The nature of the species formed with Tc-99 and "no-carrier-added"[Tc-99m]pertechnetate is different as confirmed by ratio TLC. From these results, it is demonstrated that sometimes it may be difficult to predict the structure of new technetium radiopharmaceuticals, especially when stannous ion is used as a reducing agent. Moreover, the natureof the chemical species may not be the same at millimolar and at nanomolar levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:37:36