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Titolo:
PERSISTENT IMPAIRMENT OF CLOMIPRAMINE DEMETHYLATION IN RECENTLY DETOXIFIED ALCOHOLIC PATIENTS
Autore:
BALANTGORGIA AE; GAY M; GEXFABRY M; BALANT LP;
Indirizzi:
UNIV GENEVA,DIV ALCOHOL CH-1211 GENEVA 4 SWITZERLAND UNIV GENEVA,INST PSYCHIAT,THERAPEUT DRUG MONITORING UNIT CH-1211 GENEVA 4 SWITZERLAND UNIV GENEVA,CLIN RES UNIT CH-1211 GENEVA 4 SWITZERLAND
Titolo Testata:
Therapeutic drug monitoring
fascicolo: 2, volume: 14, anno: 1992,
pagine: 119 - 124
SICI:
0163-4356(1992)14:2<119:PIOCDI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUIN HYDROXYLATION; AMITRIPTYLINE METABOLISM; PLASMA-CONCENTRATION; DEPRESSIVE PATIENTS; IMIPRAMINE; DESIPRAMINE; PHENOTYPE;
Keywords:
CLOMIPRAMINE; ALCOHOL; INTERACTION; METABOLISM; HYDROXYLATION; DEMETHYLATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A.E. Balantgorgia et al., "PERSISTENT IMPAIRMENT OF CLOMIPRAMINE DEMETHYLATION IN RECENTLY DETOXIFIED ALCOHOLIC PATIENTS", Therapeutic drug monitoring, 14(2), 1992, pp. 119-124

Abstract

The purpose of the present study was to investigate whether the metabolism of clomipramine is altered by chronic alcohol drinking. Eleven recently detoxified alcoholic patients were included (experimental group EG) and compared to a reference group of patients with no history ofalcoholism (reference group RG, n = 102). Blood concentrations of clomipramine and its metabolites were measured as part of the routine drug monitoring program. Clearances were estimated from trough concentrations, according to a model developed previously. Results indicate strong inhibition of demethylation clearance in group EG, when compared togroup RG (median values 9.9 and 24.2 L/h), with significant increase of the clomipramine to desmethylclomipramine ratio (median values 1.00and 0.36). No difference was found for hydroxylation. In addition, high correlation is observed between hydroxylation and demethylation clearances in group EG (Spearman r(s) = 0.82), but not in reference groupRG (r(s) = 0.29). Follow-up data indicate that impairment of demethylation capacity can persist for several weeks or months after withdrawal from alcohol. The interest of calculating clomipramine to desmethylclomipramine ratios during routine drug monitoring is emphasized, values of 1 or larger often being associated with liver disease and/or alcohol-related problems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:12:54