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Titolo:
HIV-1 REVERSE-TRANSCRIPTASE INHIBITING ANTIBODY TITER IN SERUM - RELATION TO DISEASE PROGRESSION AND TO CORE-ANTIBODY LEVELS
Autore:
NEUMULLER M; KARLSSON A; LENNERSTRAND J; KALLANDER CFR; SANDSTROM E; HOLMBERG V; GRONOWITZ JS;
Indirizzi:
UNIV UPPSALA,CTR BIOMED,REPLICAT ENZYMOL RES UNIT,BOX 584 S-75123 UPPSALA SWEDEN SODER SJUKHUSET,DEPT DERMATOVENEREOL STOCKHOLM SWEDEN
Titolo Testata:
Journal of medical virology
fascicolo: 4, volume: 36, anno: 1992,
pagine: 283 - 291
SICI:
0146-6615(1992)36:4<283:HRIATI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN IMMUNODEFICIENCY VIRUS; SEROPOSITIVE HOMOSEXUAL MEN; AIDS; ASSOCIATION; ANTIGENS; COHORT; PREDICTORS; INFECTION; MARKERS;
Keywords:
HIV ANTIBODIES; REVERSE TRANSCRIPTASE; PROGRESSION MARKER; HIV PROGRESSION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M. Neumuller et al., "HIV-1 REVERSE-TRANSCRIPTASE INHIBITING ANTIBODY TITER IN SERUM - RELATION TO DISEASE PROGRESSION AND TO CORE-ANTIBODY LEVELS", Journal of medical virology, 36(4), 1992, pp. 283-291

Abstract

A new assay for detecting inhibition of reverse transcriptase activity (the RT-i REA) was developed. This assay was standardized for screening serum samples for reverse transcriptase inhibiting antibodies (RT-iAb). High specificity (100%) and sensitivity (> 98%) were achieved with samples from HIV-negative individuals and HIV-infected individuals. The RT-i REA was also used in a study of the titers of RT-iAb in serum samples obtained from 33 HIV-infected homosexual men. The results confirmed the relation between decreasing RT-iAb levels and progression to late stages of the disease. Furthermore, a falling RT-iAb titer wasobserved in 14 of 15 individuals experiencing periods of severe clinical symptoms attributed to HIV-activity. In 7 of the patients the decline in RT-iAb titer began prior to severe clinical symptoms. The fall in RT-iAb titer also correlated with a reduction in core Ab level. Thecore Ab level has previously been reported to be a disease progression marker with considerable prognostic value. However, whereas all patients were positive for RT-iAb, 8 of the 33 patients did not have detectable core Ab. The use of RT-iAb titer as a marker of disease progression is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:57:59