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Titolo:
TOLERANCE TO AND DEPENDENCE ON MK-801 (DIZOCILPINE) IN RATS
Autore:
WESSINGER WD;
Indirizzi:
UNIV ARKANSAS MED SCI HOSP,DEPT PHARMACOL & TOXICOL,SLOT 611,4301 W MARKHAM ST LITTLE ROCK AR 72205
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 49, anno: 1994,
pagine: 1049 - 1056
SICI:
0091-3057(1994)49:4<1049:TTADOM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISCRIMINATIVE STIMULUS PROPERTIES; PHENCYCLIDINE-LIKE; RHESUS-MONKEYS; BEHAVIORAL DEPENDENCE; MORPHINE-TOLERANCE; NMDA RECEPTOR; PHYSICAL-DEPENDENCE; ANTAGONIST; ASPARTATE; ANTICONVULSANT;
Keywords:
RATS; BEHAVIORAL PHARMACOLOGY; SCHEDULE-CONTROLLED BEHAVIOR; FIXED-RATIO; MK-801; DIZOCILPINE; DRUG DEPENDENCE; DRUG TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
W.D. Wessinger, "TOLERANCE TO AND DEPENDENCE ON MK-801 (DIZOCILPINE) IN RATS", Pharmacology, biochemistry and behavior, 49(4), 1994, pp. 1049-1056

Abstract

Rats were trained to respond under a fixed-ratio 30 schedule for foodpresentation during four daily 0.5-h sessions occurring every 6 h. After stable baseline response was established, osmotic minipumps were implanted that infused vehicle or (+)-5 0,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-10-imine hydrogen maleate (dizocilpine; MK-801), SC. Behavioral sessions continued to be conducted daily. After 10 days the infusion pumps were removed. Vehicle and 0.10 mg/kg per day MK-801 did not affect behavior during infusions or after cessation of dosing. Dosing with 0.32 and 0.56 mg/kg per day initially suppressed responding, but tolerance developed to these effects. After the infusions were stopped, a dose-dependent disruption of operant behavior occurred. Response rates for the 0.32 and 0.56 mg/kg per day infusion groups were suppressed to 41 and 27% of preinfusion control response rates, respectively, the day after dosing stopped; however, no physical signs of abstinencewere observed. Response rates recovered toward control over the next 2-4 days. In a separate experiment, the suppression of response produced by abstinence from 0.32 mg/kg per day of MK-801 (SC) for 10.5 days was reversed by readministration of MK-801 (IP). These results demonstrate that MK-801 produces dependence, as evidenced by the emergence ofa behavioral abstinence syndrome after cessation of dosing.

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Documento generato il 28/11/20 alle ore 04:46:51