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Titolo:
BLOCKADE OF CANNABINOID-INDUCED ANTINOCICEPTION BY NALOXONE BENZOYLHYDRAZONE (NALBZH)
Autore:
WELCH SP;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,BOX 613,MCV STN RICHMOND VA 23298
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 49, anno: 1994,
pagine: 929 - 934
SICI:
0091-3057(1994)49:4<929:BOCABN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
KAPPA-OPIOID RECEPTOR; NOR-BINALTORPHIMINE; RAT-BRAIN; BINDING; AGONIST; OPIATE; MICE; ANTAGONIST; ANALGESIA; SUBTYPES;
Keywords:
CANNABINOIDS; NALOXONE BENZOYLHYDRAZONE; U50,488H; ANTINOCICEPTION; INTRATHECAL ADMINISTRATION; NOR-BINALTORPHIMINE; KAPPA RECEPTOR SUBTYPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
S.P. Welch, "BLOCKADE OF CANNABINOID-INDUCED ANTINOCICEPTION BY NALOXONE BENZOYLHYDRAZONE (NALBZH)", Pharmacology, biochemistry and behavior, 49(4), 1994, pp. 929-934

Abstract

We have recently shown that the antinociceptive effects, but not other behavioral effects of the intrathecally administered, but not intracerebroventricularly administered, cannabinoids, are blocked by the kappa antagonist, nor-binaltorphimine. We employed naloxone benzoylhydrazone, a kappa(3) agonist, and kappa(1), mu, and delta antagonist, to better characterize the interaction of cannabinoids with kappa receptors. Naloxone benzoylhydrazone blocked the antinociceptive effects of both intrathecally and intracerebroventricularly administered cannabinoids. Because the cannabinoids are not blocked by mu and delta antagonists, the effects of naloxone benzoylhydrazone are presumed to occur through interaction with kappa receptors. Because the data indicate that naloxone benzoylhydrazone does not block kappa(3) receptors, the data indicate that the cannabinoids may interact with kappa, receptors in the production of antinociception. However, differences in the profile of activity of naloxone benzoylhydrazone and the cannabinoids at kappa receptors exist. Thus, the exact nature of the interaction of the cannabinoids and the kappa receptors remains to be elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:34:48