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Titolo:
EFFECT OF NICOTINE, LOBELINE, AND MECAMYLAMINE ON SENSORY GATING IN THE RAT
Autore:
CURZON P; KIM DJB; DECKER MW;
Indirizzi:
ABBOTT LABS,DEPT NEUROSCI,DIV PHARMACEUT PROD,BLDG AP-9A 47W ABBOTT PK IL 60064
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 49, anno: 1994,
pagine: 877 - 882
SICI:
0091-3057(1994)49:4<877:EONLAM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUNGAROTOXIN BINDING-SITES; ACOUSTIC STARTLE REFLEX; CENTRAL NERVOUS-SYSTEM; FREELY MOVING RATS; PREPULSE INHIBITION; ALPHA-BUNGAROTOXIN; RECEPTOR BLOCKADE; DOPAMINE RELEASE; BRAIN; MOUSE;
Keywords:
NICOTINE; LOBELINE; MECAMYLAMINE; ACOUSTIC STARTLE; SCHIZOPHRENIA; SENSORIMOTOR GATING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
P. Curzon et al., "EFFECT OF NICOTINE, LOBELINE, AND MECAMYLAMINE ON SENSORY GATING IN THE RAT", Pharmacology, biochemistry and behavior, 49(4), 1994, pp. 877-882

Abstract

In normal subjects, if an acoustic startle stimulus is immediately preceded by a small brief change in background noise intensity, the magnitude of the subsequent startle response is decreased. This prepulse inhibition (PPI) of an acoustic startle response has been shown to be associated with sensorimotor gating. PPI is disrupted in schizophrenic patients and has been linked to attentional disorders characteristic of this disease. We tested the effects of (-)-nicotine, (0.19, 0.62, and 1.9 pmol/kg IP) (equivalent to 0.03, 0.1, and 0.3 mg/kg base) and the nicotinic cholinergic receptor (nAChR) channel blocker, mecamylamine(5.0 and 50 mu mol/kg IP) (equivalent to 1.0 and 10.0 mg/kg) on PPI of the acoustic startle response in the rat. Nicotine increased the PPIat the lowest prepulse signal levels but not at the stronger levels. Mecamylamine was without effect at 5.0 mu mol/kg, but the 50 pmol/kg dose decreased the inhibition at both weak and strong prepulse (PP) levels. Mecamylamine (5.0 mu mol/kg) pretreatment did not block the (-)-nicotineinduced increase in PPI. Lobeline (0.19, 0.62, 1.9, and 6.2 mu mol/kg IP) (equivalent to 0.071, 0.23, 0.71, and 2.3 mg/kg) was without effect. These results are consistent with a mecamylamine-insensitiveeffect of nicotine to improve gating in normal rats. The nAChR subtype involved in producing nicotine's increase of PPI needs further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:22:33