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Titolo:
INFLUENCE OF HOST-CELL TYPE AND V3 LOOP OF THE SURFACE GLYCOPROTEIN ON SUSCEPTIBILITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TO POLYANION COMPOUNDS
Autore:
MEYLAN PRA; KORNBLUTH RS; ZBINDEN I; RICHMAN DD;
Indirizzi:
CHU VAUDOIS,DEPT MED INTERNE,INST MICROBIOL,AVE BUGNON 46 CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,DEPT MED INTERNE,DIV MALAD INFECT CH-1011 LAUSANNE SWITZERLAND UNIV CALIF SAN DIEGO,SCH MED,DEPT MED SAN DIEGO CA 92093 UNIV CALIF SAN DIEGO,SCH MED,DEPT PATHOL SAN DIEGO CA 92093 SAN DIEGO VET AFFAIRS MED CTR SAN DIEGO CA 92093
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 12, volume: 38, anno: 1994,
pagine: 2910 - 2916
SICI:
0066-4804(1994)38:12<2910:IOHTAV>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT SOLUBLE CD4; AIDS-RELATED COMPLEX; ANTI-HIV ACTIVITY; DEXTRAN SULFATE; INFECTION; INVITRO; GP120; TROPISM; DOMAIN; POLYSACCHARIDES;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P.R.A. Meylan et al., "INFLUENCE OF HOST-CELL TYPE AND V3 LOOP OF THE SURFACE GLYCOPROTEIN ON SUSCEPTIBILITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TO POLYANION COMPOUNDS", Antimicrobial agents and chemotherapy, 38(12), 1994, pp. 2910-2916

Abstract

Dextran sulfate is a potent inhibitor of human immunodeficiency virus(HIV) binding and replication in lymphocytic cell lines. In this study, we demonstrate that the effect of dextran sulfate and heparin depends on the host cell type and on the V3 loop, the principal neutralizing determinant of HIV gp120. In particular, when dextran sulfate was tested on primary human macrophages infected,vith macrophage-tropic viruses, enhancement of infection was observed in 6 of 11 independent macrophage preparations and mith 5 of 13 primary HIV isolates. Our in vitro observations might explain why enhanced HIV replication was observedin HIV-infected patients treated with dextran sulfate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:41:11