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Titolo:
CHARACTERIZATION OF THE PNT1 PENTAMIDINE RESISTANCE GENE OF SACCHAROMYCES-CEREVISIAE
Autore:
LUDEWIG G; STABEN C;
Indirizzi:
UNIV KENTUCKY,TH MORGAN SCH BIOL SCI,101 MORGAN BLDG LEXINGTON KY 40506 UNIV KENTUCKY,TH MORGAN SCH BIOL SCI LEXINGTON KY 40506
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 12, volume: 38, anno: 1994,
pagine: 2850 - 2856
SICI:
0066-4804(1994)38:12<2850:COTPPR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PNEUMOCYSTIS-CARINII PNEUMONIA; SHUTTLE VECTORS; YEAST; SENSITIVITY; PROTEIN; BRUCEI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G. Ludewig e C. Staben, "CHARACTERIZATION OF THE PNT1 PENTAMIDINE RESISTANCE GENE OF SACCHAROMYCES-CEREVISIAE", Antimicrobial agents and chemotherapy, 38(12), 1994, pp. 2850-2856

Abstract

The Saccharomyces cerevisiae PNT1 gene was isolated and characterized. When present in high copy number in S. cerevisiae, PNT1 confers resistance to the anti-Pneumocystis carinii drug pentamidine. The PNT1 gene encodes a previously uncharacterized polypeptide of 409 amino acids. The predicted gene product is a very basic (pI 9.9) polypeptide with one potential membrane-associated region. PNT1 is located on chromosome XVR of S. cerevisiae. It is transcribed at a very low level. Overexpression of the gene increases resistance to the cytostatic and mitochondrial DNA-damaging effects of pentamidine and related cationic compounds. Disruption of the gene leads to slightly increased levels of susceptibility to pentamidine and some related compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:28:44