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Titolo:
QUANTIFICATION, QUALIFICATION, AND MICROBIAL KILLING EFFICIENCIES OF ANTIMICROBIAL CHLORINE-BASED SUBSTANCES PRODUCED BY IONTOPHORESIS
Autore:
DAVIS CP; SHIRTLIFF ME; TRIEFF NM; HOSKINS SL; WARREN MM;
Indirizzi:
UNIV TEXAS,MED BRANCH,DEPT MICROBIOL & IMMUNOL GALVESTON TX 77555 UNIV TEXAS,MED BRANCH,DEPT PREVENT MED,DIV ENVIRONM TOXICOL GALVESTONTX 77555 UNIV TEXAS,MED BRANCH,DEPT SURG GALVESTON TX 77555
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 12, volume: 38, anno: 1994,
pagine: 2768 - 2774
SICI:
0066-4804(1994)38:12<2768:QQAMKE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTERIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C.P. Davis et al., "QUANTIFICATION, QUALIFICATION, AND MICROBIAL KILLING EFFICIENCIES OF ANTIMICROBIAL CHLORINE-BASED SUBSTANCES PRODUCED BY IONTOPHORESIS", Antimicrobial agents and chemotherapy, 38(12), 1994, pp. 2768-2774

Abstract

The dependence of microbial killing on chloride ions present in solutions undergoing iontophoresis is addressed. A 400-mu A current was applied to vials containing synthetic urine or saline, and the productionof chlorine-based substances (CBSs) was detected by the N,N-diethyl-p-phenylene diamine colorimetric method. It was found that as the time of current application increased, the total concentration of CBSs alsoincreased. The iontophoretic current converted (through oxidation) chloride ions present in the solutions into CBSs such as free chlorine, chlorine dioxide, chlorite, monochloramine, and dichloramine (the lasttwo were produced by iontophoresis only when nitrogenous substances were present in the solution). Two of the CBSs (free Cl and ClO2), whenthey were separately added back to microbial suspensions (approximately 3 x 10(5) CFU/ml) at the same concentrations at which they were detected in either 0.46% (wt/vol) NaCl solution or synthetic urine iontophoresed for 4 h at 400 mu A, reduced or eliminated bacterial genera and a fungus. However, when free Cl and ClO2 were jointly added back to microbial suspensions, bacterial and fungal killing was synergistic and more rapid and complete than when these chlorine-based biocides wereadded separately. Therefore, iontophoresis of solutions containing chloride ions produces chlorine-based biocides that are responsible for the antimicrobial effect of iontophoresis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 08:52:54