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Titolo:
CLARITHROMYCIN, DAPSONE, AND A COMBINATION OF BOTH USED TO TREAT OR PREVENT DISSEMINATED MYCOBACTERIUM-AVIUM INFECTION IN BEIGE MICE
Autore:
BERMUDEZ LE; INDERLIED CB; KOLONOSKI P; PETROFSKY M; YOUNG LS;
Indirizzi:
CALIF PACIFIC MED CTR,RES INST,KUZELL INST ARTHRIT & INFECT DIS,2200 WEBSTER ST,SUITE 305 SAN FRANCISCO CA 94115 UNIV SO CALIF,CHILDRENS HOSP LOS ANGELES,DEPT PATHOL & LAB MED LOS ANGELES CA 90027
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 12, volume: 38, anno: 1994,
pagine: 2717 - 2721
SICI:
0066-4804(1994)38:12<2717:CDAACO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; COMPLEX INFECTION; INVITRO; ETHAMBUTOL; INTRACELLULARE; AZITHROMYCIN; CLOFAZIMINE; RIFABUTIN; RIFAMPIN; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Bermudez et al., "CLARITHROMYCIN, DAPSONE, AND A COMBINATION OF BOTH USED TO TREAT OR PREVENT DISSEMINATED MYCOBACTERIUM-AVIUM INFECTION IN BEIGE MICE", Antimicrobial agents and chemotherapy, 38(12), 1994, pp. 2717-2721

Abstract

Bacteremic infection caused by organisms of the Mycobacterium avium complex (MAC) is common in patients with AIDS. We evaluated both clarithromycin and dapsone alone and in combination for the treatment and prevention of disseminated MAC disease in beige mice. In the therapeuticmodel, C57BL/6 beige mice were infected intravenously with strain 101of MAC (serovar 1). After 1 week postinfection, mice were given clarithromycin (200 mg/kg of body weight per day) and dapsone (15 mg/kg of body weight per day) alone or in combination by Savage. Treatment withclarithromycin resulted in a significant reduction in bacteremia and the numbers of CFU of MAC in the liver and spleen. Treatment with dapsone had no effect on the mycobacterial counts in blood, liver, or spleen, and the combination of dapsone with clarithromycin was no better than clarithromycin as a single agent. Clarithromycin and dapsone were used to prevent systemic disease in beige mice infected orally with MAC 101. Clarithromycin prophylaxis was associated with a significant reduction in the numbers of bacteria in the liver, spleen, and appendix compared with those in controls. Prophylaxis with dapsone resulted in a mild reduction in the numbers of MAC in the spleen but not in the other tissues. Clarithromycin both treats and prevents MAC disease in beige mice. Dapsone has no therapeutic effect, but it does have a slightprophylactic effect, and in combination with clarithromycin it does not abrogate the effect of clarithromycin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:07:24