Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GENETIC BASES OF EPIDERMOLYSIS-BULLOSA SIMPLEX AND EPIDERMOLYTIC HYPERKERATOSIS
Autore:
FUCHS E; COULOMBE P; CHENG J; CHAN YM; HUTTON E; SYDER A; DEGENSTEIN L; YU QC; LETAI A; VASSAR R;
Indirizzi:
UNIV CHICAGO,HOWARD HUGHES MED INST,DEPT MOLEC GENET & CELL BIOL,5841S MARYLAND AVE,ROOM N314 CHICAGO IL 60637
Titolo Testata:
Journal of investigative dermatology
fascicolo: 5, volume: 103, anno: 1994, supplemento:, S
pagine: 190000025 - 190000030
SICI:
0022-202X(1994)103:5<190000025:GBOESA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL ICHTHYOSIFORM ERYTHRODERMA; INTERMEDIATE FILAMENT STRUCTURE; WEBER-COCKAYNE; DOWLING-MEARA; KERATIN GENES; EPIDERMAL KERATINS; ASSEMBLY INVITRO; POINT MUTATIONS; CROSS-LINKING; ROD DOMAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
E. Fuchs et al., "GENETIC BASES OF EPIDERMOLYSIS-BULLOSA SIMPLEX AND EPIDERMOLYTIC HYPERKERATOSIS", Journal of investigative dermatology, 103(5), 1994, pp. 190000025-190000030

Abstract

Keratins are the major structural proteins of the epidermis. Analyzing keratin gene sequences, appreciating the switch in keratin gene expression that takes place as epidermal cells commit to terminally differentiate, and elucidating how keratins assemble into 10-nm filaments have provided the foundation that has led to the discoveries of the genetic bases of two major classes of human skin diseases. In this report,we review the cell biology and human genetics of these diseases, epidermolysis bullosa simplex and epidermolytic hyperkeratosis. Both of these diseases are epidermal disorders of keratin, typified by cell fragility as a consequence of defects in the mechanical strength of basal epidermolysis bullosa simplex or suprabasal epidermolytic hyperkeratosis cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 23:47:46