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Titolo:
TECHNETIUM 94M-LABELED METHOXYISOBUTYL ISONITRILE - DOSIMETRY AND RESTING CARDIAC IMAGING WITH POSITRON EMISSION TOMOGRAPHY
Autore:
STONE CK; CHRISTIAN BT; NICKLES RJ; PERLMAN SB;
Indirizzi:
UNIV WISCONSIN,SCH MED,CTR CLIN SCI,DEPT MED,CARDIOL SECT,600 HIGHLAND AVE MADISON WI 53792 UNIV WISCONSIN,SCH MED,DEPT RADIOL,NUCL MED SECT MADISON WI 53792 UNIV WISCONSIN,SCH MED,DEPT MED PHYS MADISON WI 53792 UNIV WISCONSIN,WILLIAM S MIDDLETON MEM VET ADM HOSP,CTR POSITRON EMISS TOMOG MADISON WI 53792
Titolo Testata:
Journal of nuclear cardiology
fascicolo: 5, volume: 1, anno: 1994,
parte:, 1
pagine: 425 - 433
SICI:
1071-3581(1994)1:5<425:T9MI-D>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEXAKIS 2-METHOXYISOBUTYL ISONITRILE; MYOCARDIAL BLOOD-FLOW; N-13 AMMONIA; PERFUSION; QUANTIFICATION; TL-201; PET; INFARCTION; DEPENDENCE; THALLIUM;
Keywords:
POSITRON EMISSION TOMOGRAPHY; NITROGEN 13-LABELED AMMONIA; TECHNETIUM 94M-LABELED SESTAMIBI; MYOCARDIAL INFARCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C.K. Stone et al., "TECHNETIUM 94M-LABELED METHOXYISOBUTYL ISONITRILE - DOSIMETRY AND RESTING CARDIAC IMAGING WITH POSITRON EMISSION TOMOGRAPHY", Journal of nuclear cardiology, 1(5), 1994, pp. 425-433

Abstract

Background. Development of a positron-emitting form of technetium hasallowed the imaging of technetium radiopharmaceuticals with positron emission tomography (PET). We used Tc-94m to compare the distribution of the myocardial perfusion agent sestamibi at rest with the conventional PET perfusion tracer N-13-labeled ammonia (N-13-ammonia). Methods and Results. Dosimetry calculations were performed with the known whole-body distribution of Tc-99m-labeled sestamibi. Dynamic PET imaging of N-13-ammonia and Tc-94m-labeled sestamibi (Tc-94m-sestamibi) for 32 minutes was performed in eight patients with previous myocardial infarction. Initial myocardial and extramyocardial distribution of Tc-94m-sestamibi was compared with that of N-13-ammonia by qualitative and quantitative analysis. Quantitative comparison of the two tracers was performed with region-of-interest analysis and circumferential profiles. Qualitatively, the cardiac distribution of the tracers was similar in normal and infarcted myocardium. A decrease in the definition of the epicardial and endocardial borders of the heart was seen with Tc-94m-sestamibi, presumably because of the lower dose of radionuclide injected. Quantitatively, there was no difference in infarct size, defined prospectively as tracer activity less than 20% of maximum activity for the section, between the two tracers. Circumferential profile analysis with 12-degree radial sections similarly demonstrated no difference in regional cardiac distribution of the tracers. Conclusions. These results revealed no significant difference in myocardial uptake compared with N-13-ammonia suggesting that the myocardial uptake of sestamibi correlates with that of myocardial perfusion.

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Documento generato il 11/07/20 alle ore 03:40:09