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Titolo:
CD34(+) SELECTED CELLS IN CLINICAL TRANSPLANTATION
Autore:
COLLINS RH;
Indirizzi:
BAYLOR UNIV,MED CTR,CHARLES A SAMMONS CANC CTR,3500 GASTON AVE,SAMMONS TOWER,SUITE 410 DALLAS TX 75246 TEXAS ONCOL PA DALLAS TX 00000
Titolo Testata:
Stem cells
fascicolo: 6, volume: 12, anno: 1994,
pagine: 577 - 585
SICI:
1066-5099(1994)12:6<577:CSCICT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; EXVIVO EXPANSION; PROGENITOR CELLS; BREAST-CANCER; HEMATOPOIETIC STEM; TUMOR-CELLS; B-CELL; BLOOD; INFUSION; RECONSTITUTION;
Keywords:
CD34 ANTIGEN; HEMATOPOIETIC STEM CELLS; BONE MARROW TRANSPLANTATION; PURGING; EXPANSION; GENE THERAPY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
R.H. Collins, "CD34(+) SELECTED CELLS IN CLINICAL TRANSPLANTATION", Stem cells, 12(6), 1994, pp. 577-585

Abstract

The CD34 antigen is expressed by early hematopoietic stem cells and progenitors and is detected on the surface of approximately 1% of bone marrow mononuclear cells [1-3]. Several monoclonal antibody-based methods have been developed to isolate these cells from clinical samples of bone marrow or peripheral blood based on their expression of this antigen, utilizing either biotin-avidin affinity, panning or immunomagnetic beads. Roughly 50% of CD34(+) cells, with 20-90% purity, are recovered from clinical samples using these methods. Several clinical trials have demonstrated hematopoietic recovery using CD34(+) selected cells to support high dose therapy. CD34(+) cells may be useful in severalareas of clinical stem cell transplantation, including purging of tumor cells, T cell depletion, stem cell expansion and gene therapy. Thispaper reviews the current methods for purification of CD34(+) cells from clinical samples and discusses potential uses of these cells in transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:41:02