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Titolo:
LIDOCAINE PROTECTS HIPPOCAMPAL-NEURONS AGAINST ISCHEMIC DAMAGE BY PREVENTING INCREASE OF EXTRACELLULAR EXCITATORY AMINO-ACIDS - A MICRODIALYSIS STUDY IN MONGOLIAN GERBILS
Autore:
FUJITANI T; ADACHI N; MIYAZAKI H; LIU KY; NAKAMURA Y; KATAOKA K; ARAI T;
Indirizzi:
EHIME UNIV,SCH MED,DEPT ANESTHESIOL & RESUSCITOL SHITSUKAWA EHIME JAPAN EHIME UNIV,SCH MED,DEPT ANESTHESIOL & RESUSCITOL SHITSUKAWA EHIME JAPAN EHIME UNIV,SCH MED,DEPT PHYSIOL SHITSUKAWA EHIME JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 179, anno: 1994,
pagine: 91 - 94
SICI:
0304-3940(1994)179:1-2<91:LPHAID>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACEREBRAL MICRODIALYSIS; CEREBRAL-ISCHEMIA; GLUTAMATE; RAT; CELLS;
Keywords:
CEREBRAL ISCHEMIA; LIDOCAINE; AMINO ACIDS; HIPPOCAMPUS; CAL; MICRODIALYSIS; MONGOLIAN GERBILS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
T. Fujitani et al., "LIDOCAINE PROTECTS HIPPOCAMPAL-NEURONS AGAINST ISCHEMIC DAMAGE BY PREVENTING INCREASE OF EXTRACELLULAR EXCITATORY AMINO-ACIDS - A MICRODIALYSIS STUDY IN MONGOLIAN GERBILS", Neuroscience letters, 179(1-2), 1994, pp. 91-94

Abstract

Extracellular levels of amino acids in the hippocampal CA1 region of the gerbil were analyzed by a microdialysis-HPLC procedure. Transient forebrain ischemia produced significant increase in aspartate, glutamate, glycine and taurine (760%, 1070%, 190% and 1210%, respectively), and neuronal blockade by perfusion with a lidocaine (4 mM)-containing medium resulted in 67%, 79%, 58% and 59% reduction in the peak values of each amino acid, respectively. On the other hand, an intracerebroventricular administration of lidocaine, 0.8 mu mol or more, produced a protective effect against delayed damage of hippocampal CA1 pyramidal cells, which was caused by bilateral carotid artery occlusion for 4 min. The results suggest that lidocaine may protect neurons against ischemic damage, by preventing the ischemia-induced rise of extracellular concentration of excitatory amino acid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:29:21