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Titolo:
THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS
Autore:
PEREIRA DS; JELINEK T; GRAHAM FL;
Indirizzi:
MCMASTER UNIV,DEPT BIOL,1280 MAIN ST W HAMILTON L8S 4K1 ON CANADA MCMASTER UNIV,DEPT BIOL HAMILTON L8S 4K1 ON CANADA MCMASTER UNIV,DEPT PATHOL HAMILTON L8S 4K1 ON CANADA
Titolo Testata:
International journal of oncology
fascicolo: 6, volume: 5, anno: 1994,
pagine: 1197 - 1205
SICI:
1019-6439(1994)5:6<1197:TAEPPI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXIC LYMPHOCYTES-T; NATURAL-KILLER-CELLS; TRANSCRIPTIONAL CONTROL; TRANSFORMED-CELLS; E1A PROTEINS; MOUSE CELLS; EXPRESSION; TUMORIGENICITY; INDUCTION; BINDING;
Keywords:
P300; E1A; ADENOVIRUS TYPE 5; ADENOVIRUS TYPE 12; PHOSPHORYLATION; MHC CLASS I;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Pereira et al., "THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS", International journal of oncology, 5(6), 1994, pp. 1197-1205

Abstract

Recently, using hybrid Ad5/12 E1A-transformed rat cells, we identified at least two regions of Ad12 E1A which influence tumorigenicity. In this report, again using the hybrid Ad5/12 E1A-transformants, we show that expression of these same two Ad12 E1A regions not only correlateswith down-regulation of cell surface MHC class I expression, but coincides with the presence of an altered form of the E1A-associated cellular protein, p300, detected as a more slowly migrating species in SDS-polyacrylamide gels. The decreased electrophoretic mobility of p300 from hybrid Ad5/12 E1A- and Ad12 E1A-transformants can be abolished by protein phosphatase treatment suggesting that the change in mobility results from differential phosphorylation of p300. We suggest that differential phosphorylation of p300 may be functionally significant in thecontext of phenotypic differences between Ad5 E1- and Ad12 E1-transformed cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:25:54