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Titolo:
CONCURRENT CISPLATINUM AND RADIATION WITH OR WITHOUT SURGERY FOR ADVANCED HEAD AND NECK-CANCER
Autore:
GLICKSMAN AS; SLOTMAN G; DOOLITTLE C; CLARK J; KONESS J; COACHMAN N; POSNER M; DEROSA E; WANEBO H;
Indirizzi:
BROWN UNIV,ROGER WILLIAMS MED CTR,DEPT RADIAT ONCOL,825 CHALKSTONE AVE PROVIDENCE RI 02908 BROWN UNIV,ROGER WILLIAMS MED CTR,DEPT MED ONCOL PROVIDENCE RI 00000 BROWN UNIV,ROGER WILLIAMS MED CTR,DEPT SURG ONCOL PROVIDENCE RI 00000 VET ADM MED CTR PROVIDENCE RI 00000
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 5, volume: 30, anno: 1994,
pagine: 1043 - 1050
SICI:
0360-3016(1994)30:5<1043:CCARWO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; TERM FOLLOW-UP; ADJUVANT CHEMOTHERAPY; CONCOMITANT CHEMORADIOTHERAPY; OROPHARYNGEAL CARCINOMA; INDUCTION CHEMOTHERAPY; RANDOMIZED TRIAL; RESECTABLE HEAD; THERAPY;
Keywords:
CHEMOTHERAPY; RADIATION; SURGERY; MULTIMODALITY THERAPY; ADVANCED HEAD AND NECK CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Glicksman et al., "CONCURRENT CISPLATINUM AND RADIATION WITH OR WITHOUT SURGERY FOR ADVANCED HEAD AND NECK-CANCER", International journal of radiation oncology, biology, physics, 30(5), 1994, pp. 1043-1050

Abstract

Purpose: This study was undertaken to assess the efficacy of concurrent cis-platinum and radiation in patients with advanced head and neck cancer and to determine if patients responding to the preoperative regimens may be cured without radical surgery. Methods and Materials: Onehundred and one patients with potentially operable Stage III and IV squamous cell carcinoma of the head and neck received 45 Gy at 1.8 Gy fractions and continuous infusion cis-platinum 20 mg/ m(2) over 24 h ondays 1 through 4 and 22 through 25 of the radiation schedule. Three to 4 weeks later, radical surgery of the primary site and neck dissections for patients presenting with cervical adenopathy was undertaken orif a complete response had been achieved, continued with radiation to72 Gy with another course of concurrent continuous infusion cis-platinum. Result: Complete and partial responses were achieved in 92% of the primary sites and 95% of the nodes. Over 80% of the patients were rendered tumor free at surgery after only the initial course of chemotherapy and radiation. There were no grade 3 or 4 toxicities from chemotherapy and radiation. Ninety-five percent of the patients who initiatedtreatment completed it. With a median follow-up of 41 months for all patients, 49% of the patients have survived disease free up to 9 years, independent of whether or not their primary tumors were resected or were treated definitively by further chemotherapy sensitized radiation. The disease-specific survival is 78% after 3 years with no local failures thereafter. Conclusion: These findings suggest that continuous infusion cis-platinum administered concurrently with radiotherapy can improve survival in advanced head and neck cancer. Patients responding to the preoperative regimen may be cured without radical surgery, which can be reserved for salvage.

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Documento generato il 29/11/20 alle ore 00:53:29